Spontaneous and stimulated CD25 expression on T-lymphocytes and the amount of regulatory T-cells in children with chronic hepatitis C

Children of 6–17 years old with viral chronic hepatitis C (n=24) and conditionally healthy controls of corresponding age (n=32) were examined. The amount of CD3+CD25+, CD4+CD25+ и CD8+CD25+ and regulatory T-cells (Treg, CD3+CD4+CD25+CD127low/neg) were investigated by fl ow cytometry. In children with chronic hepatitis C the number of phytohemagglutinin-stimulated CD3+CD25+, CD4+CD25+ and Treg was decreased, the amount of CD8+CD25+ in conditions of stimulation by antibodies to CD3 and combined stimulation by antibodies to CD3 and CD28 was too decreased.

Keywords

hepatitis C, lymphocytes, fl ow cytometry, Treg

Received

11.01.2019

Publication date

12.01.2019

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GOST	Pashnina I. Spontaneous and stimulated CD25 expression on T-lymphocytes and the amount of regulatory T-cells in children with chronic hepatitis C // Rossiiskii immunologicheskii zhurnal – 2018. – V. 12. – Issue 3 C. 385-390 [Electronic resource]. URL: http://ras.jes.su/ruimm/s207987840001609-8-1-en (circulation date: 24.04.2024). DOI: 10.31857/S102872210002415-1
MLA	Pashnina, I. "Spontaneous and stimulated CD25 expression on T-lymphocytes and the amount of regulatory T-cells in children with chronic hepatitis C." Rossiiskii immunologicheskii zhurnal 12.3 (2018):385-390. DOI: 10.31857/S102872210002415-1
APA	Pashnina I. (2018). Spontaneous and stimulated CD25 expression on T-lymphocytes and the amount of regulatory T-cells in children with chronic hepatitis C. Rossiiskii immunologicheskii zhurnal 12(3), pp.385-390 DOI: 10.31857/S102872210002415-1

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