Peripheral blood cytotoxic T cells in patients with sarcoidosis

 
PIIS102872210002408-3-1
DOI10.31857/S102872210002408-3
Publication type Article
Status Published
Authors
Affiliation:
Academician I.P. Pavlov First St. Petersburg State Medical University
State Research Institute of Highly Pure Biopreparations
Affiliation:
Academician I.P. Pavlov First St. Petersburg State Medical University
Institute of Experimental Medicine
Affiliation: Academician I.P. Pavlov First St. Petersburg State Medical University
Affiliation: Institute of Experimental Medicine
Affiliation:
Academician I.P. Pavlov First St. Petersburg State Medical University
State Research Institute of Highly Pure Biopreparations
Affiliation: Academician I.P. Pavlov First St. Petersburg State Medical University
Affiliation:
Academician I.P. Pavlov First St. Petersburg State Medical University
St. Petersburg Pasteur Institute
Journal nameRossiiskii immunologicheskii zhurnal
EditionVolume 12 Issue 3
Pages348-353
Abstract

Based on CD45RA, CD62L, CD27 и CD28 expression several subsets of peripheral blood CD3+CD8+ lymphocytes were measured in patients with chronic sarcoidosis (n=46). The percentage of “non-eff ector” CD3+CD8+ subsets – “naïve” and central memory – were decreased in comparison with healthy control group (n=46), whereas the relative number of TEMRA cells was signifi cantly increased. Within EM subset percentage of EM1 cells was lower in sarcoidosis group, while among TEMRA the relative number of рЕ2 and mature eff ector cells were increased if compared with healthy control group. Thereby, our results indicate the intensifi cation of CD3+CD8+ lymphocytes maturation in the lymphoid tissue under a constant antigenic stimulation.

Keywordssarcoidosis, cytotoxic T cells, CD45RA и CD62L, CD27 и CD28, flow cytometry
Received11.01.2019
Publication date12.01.2019
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