Peripheral blood cytotoxic T cells in patients with sarcoidosis

Based on CD45RA, CD62L, CD27 и CD28 expression several subsets of peripheral blood CD3+CD8+ lymphocytes were measured in patients with chronic sarcoidosis (n=46). The percentage of “non-eff ector” CD3+CD8+ subsets – “naïve” and central memory – were decreased in comparison with healthy control group (n=46), whereas the relative number of TEMRA cells was signifi cantly increased. Within EM subset percentage of EM1 cells was lower in sarcoidosis group, while among TEMRA the relative number of рЕ2 and mature eff ector cells were increased if compared with healthy control group. Thereby, our results indicate the intensifi cation of CD3+CD8+ lymphocytes maturation in the lymphoid tissue under a constant antigenic stimulation.

Keywords

sarcoidosis, cytotoxic T cells, CD45RA и CD62L, CD27 и CD28, flow cytometry

Received

11.01.2019

Publication date

12.01.2019

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GOST	Lazareva N., Kudryavtsev I., Baranova O., Serebriakova M., Ses’ T., Ilkovich M., Totolyan A. Peripheral blood cytotoxic T cells in patients with sarcoidosis // Rossiiskii immunologicheskii zhurnal – 2018. – V. 12. – Issue 3 C. 348-353 [Electronic resource]. URL: http://ras.jes.su/ruimm/s207987840001602-1-1-en (circulation date: 25.04.2024). DOI: 10.31857/S102872210002408-3
MLA	Lazareva, N., Kudryavtsev, I., Baranova, O., Serebriakova, M., Ses’, T., Ilkovich, M., Totolyan, A. "Peripheral blood cytotoxic T cells in patients with sarcoidosis." Rossiiskii immunologicheskii zhurnal 12.3 (2018):348-353. DOI: 10.31857/S102872210002408-3
APA	Lazareva N., Kudryavtsev I., Baranova O., Serebriakova M., Ses’ T., Ilkovich M., Totolyan A. (2018). Peripheral blood cytotoxic T cells in patients with sarcoidosis. Rossiiskii immunologicheskii zhurnal 12(3), pp.348-353 DOI: 10.31857/S102872210002408-3

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