Neonatal Lethality and Inflammatory Phenotype of New Transgenic Mice with Overexpression of Human Interleukin-6 in Myeloid Cells

 
PIIS086956520003288-9-1
DOI10.31857/S086956520003288-9
Publication type Article
Status Published
Authors
Affiliation:
Engelhardt Institute of Molecular Biology, RAS
Lomonosov Moscow State University
Address: Russian Federation
Occupation: Leading researcher, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Address: Russian Federation, Moscow
Affiliation: Institute of Gene Biology, Russian Academy of Sciences
Address: Russian Federation
Occupation: PhD student, Department of Immunology, Biological Faculty, Lomonosov Moscow State University; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University
Affiliation:
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Lomonosov Moscow State University
Address: Russian Federation, Moscow
Affiliation:
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Lomonosov Moscow State University
Address: Russian Federation
Affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Address: Russian Federation
Affiliation: Institute of Gene Biology, Russian Academy of Sciences
Address: Russian Federation
Affiliation: Institute of Gene Biology, Russian Academy of Sciences
Address: Russian Federation
Affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Address: Russian Federation
Affiliation:
Engelhardt Institute of Molecular Biology, RAS
Lomonosov Moscow State University
Address: Russian Federation
Affiliation: Institute of Gene Biology, Russian Academy of Sciences
Address: Russian Federation
Journal nameDoklady Akademii nauk
EditionVolume 483 Issue 4
Pages462-465
Abstract

  

Keywords
Received21.12.2018
Publication date21.12.2018
Number of characters570
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1. Korneev K.V., Sviryaeva E.N., Drutskaya M.S., Kuprash D.V., Nedospasov S.A. Razrabotka sistemy dlya indutsiruemoj Cre-zavisimoj produktsii interlejkina-6 cheloveka v kletkakh myshi i cheloveka. // Rossijskij immunol. zhur. 2016. T. 10. No 2(19). S. 188–192.

2. Gu H., Zou Y.R., Rajewsky K. Independent Control of Immunoglobulin Switch Recombination at Individual Switch Regions Evidenced Through Cre-loxP-mediated Gene Targeting. // Cell. 1993. V. 73. No 6. P. 1155–1164.

3. Chung J.H., Whiteley M., Felsenfeld G. A 5’ Element of the Chicken Beta-Globin Domain Serves as an Insulator in Human Erythroid Cells and Protects Against Position Effect in Drosophila. // Cell. 1993. V. 74. No 3. P. 505–514.

4. Drutskaya M.S., Nosenko M.A., Atretkhany K.-S.N., Efimov G.A., Nedospasov S.A. Interlejkin-6 – ot molekulyarnykh mekhanizmov peredachi signala k fiziologicheskim funktsiyam i terapevticheskim mishenyam. // Molekulyarnaya biologiya. 2015. T. 49. No 6. S. 937–943.

5. Zvezdova E.S., Silaeva Yu.Yu., Vagida M.S., Maryukhnich E.V., Dejkin A.V., Ermolkevich T.G., Kadulin S.G., Sadchikova E.R., Gol'dman I.L., Kazanskij D.B. Sozdanie transgennykh zhivotnykh, sinteziruyuschikh a – i b – tsepi autoreaktivnogo T-kletochnogo retseptora. // Molekulyar. biologiya. 2010. T. 44. No 2. S. 311–322.

6. Clausen B.E., Burkhardt C., Reith W., Renkawitz R., Forster I. Conditional Gene Targeting in Macrophages and Granulocytes Using LysMcre Mice. // Transgenic Res. 1999. V. 8. No 4. P. 265–277.

7. Grivennikov S.I., Tumanov A.V., Liepinsh D.J., Kruglov A.A., Marakusha B.I., Shakhov A.N., Murakami T., Drutskaya L.N., Forster I., Clausen B.E., Tessarollo L., Ryffel B., Kuprash D.V., Nedospasov S.A. Distinct and Nonredundant in Vivo Functions of TNF Produced by t Cells and Macrophages/Neutrophils: Protective and Deleterious Effects. // Immunity. 2005. V. 22. No 1. P. 93–104.

8. Kyoizumi S., Murray L.J., Namikawa R. Preclinical Analysis of Cytokine Therapy in the SCID-hu Mouse. // Blood. 1993. V. 81. No 6. P. 1479–1488.

9. Ganz T., Nemeth E. Iron Homeostasis in Host Defence and Inflammation. // Nat ReV. Immunol. 2015. V. 15. No 8. P. 500–10.

10. Metzger D., Clifford J., Chiba H., Chambon P. Conditional Site-Specific Recombinationin Mammalian Cells Using a Ligand-Dependent Chimeric CreRecombinase. // Proc. Natl. Acad. Sci. USA. 1995. V. 92. No 15. P. 6991–6995.

11. Yona S., Kim K.W., Wolf Y., Mildner A., Varol D., Breker M., Strauss-Ayali D., Viukov S., Guilliams M., Misharin A., Hume D.A., Perlman H., Malissen B., Zelzer E., Jung S. Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under homeostasis. // Immunity. 2013. V. 38. No 1. P. 79–91.

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