Immunotoxic effect of carbon tetrachloride

 
PIIS102872210002433-1-1
DOI10.31857/S102872210002433-1
Publication type Article
Status Published
Authors
Affiliation:
Ural Federal University named after the first President of Russia Boris Yeltsin
Institute of Immunology and Physiology, Ural Branch of RAS
Affiliation:
Ural Federal University named after the first President of Russia Boris Yeltsin
Institute of Immunology and Physiology, Ural Branch of RAS
Affiliation:
Ural Federal University named after the first President of Russia Boris Yeltsin
Institute of Immunology and Physiology, Ural Branch of RAS
Journal nameRossiiskii immunologicheskii zhurnal
EditionVolume 12 Issue 3
Pages493-499
Abstract

This article presents an estimate of the number of cells with the content of heat shock protein HSP70, as well as the level of tumor necrosis factor TNF-α and IL-10 under conditions of intoxication with tetrachloromethane (CCl4). It was shown that the number of cells containing HSP70 protein granules signifi cantly increased in the thymus and spleen cells on day 3 after administration of the toxicant. The toxic eff ect of CCl4 leads to an increase in the level of TNF-α and a decrease in IL-10 in blood plasma. The results showed that the response of the body to intraperitoneal administration of CCl4 is manifested by an increase in the production of HSP70 and TNF-α, which can serve as markers of cellular damage and has prognostic and diagnostic signifi cance.

Keywordscarbon tetrachloride, thymus, spleen, HSP70, TNF-α
AcknowledgmentThe study was conducted as part of the budget program "Study of the mechanisms of regenerative processes in organs and tissues using experimental models of extreme factors and toxic effects on the body", No. Gos. registrations - АААА-А18– 118020590107–0.
Received12.01.2019
Publication date12.01.2019
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