Miliacin triterphenoid as a means of improving effective impact on bacterial intestinal infection

 
PIIS102872210002429-6-1
DOI10.31857/S102872210002429-6
Publication type Article
Status Published
Authors
Affiliation: Orenburg State Medical University
Affiliation: Orenburg State Medical University
Affiliation:
Orenburg State Medical University
Institute of Cellular and Intracellular Symbiosis
Affiliation: Orenburg State Medical University
Affiliation: Orenburg State Medical University
Affiliation: Orenburg State Medical University
Affiliation: Orenburg State Medical University
Affiliation: Orenburg State Medical University
Journal nameRossiiskii immunologicheskii zhurnal
EditionVolume 12 Issue 3
Pages466-470
Abstract

Triterpenoid of vegetable origin miliacin has a protective eff ect in experimental salmonella infection, manifested by a decrease in: animal death, organ contamination, bone marrow hypoplasia, thymus, endotoxinemia, nitric oxide production by macrophages, accumulation of oxidative stress products. The immunomodulatory eff ect of miliacin is combined with a modifying effect on the biological properties of salmonella.

Keywordstriterpenoid miliacin, infection, salmonellosis, immune defense
Received12.01.2019
Publication date12.01.2019
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1. Rozhnova S. Sh., Guseva A. N., Khristyukhina O. A., Vitkova O. N., Krutova N. E. Rol' sovremennykh metodov tipirovaniya v izuchenii geneticheskogo raznoobraziya i chuvstvitel'nosti k antibiotikam shtammov sal'monell, vydelennykh iz raznykh istochnikov. Ehpidemiologiya i infektsionnye bolezni. Aktual'nye voprosy 2017, 3, 15–24. [Rozhnova S. Sh., Guseva A. N., Khristiukhina O. A., Vitkova O. N., Krutova N. E. The role of modern typing methods in the study of genetic diversity and susceptibility to antibiotics of Salmonella strains isolated from diff erent sources. Epidemiology and infectious diseases. Current issues 2017, 3, 15–24].

2. Jackson B. R., Griffi n P. M., D. Cole, Walsh K. A., Chai S. J. Outbreak – associated Salmonells Enterica Serotypes and Food Commodities United States, 1990– 2008. Ermeg. Infect. Dis. 2013, 19 (8), 1239–1244.

3. Zheleznova A. D. Ehksperimental'noe obosnovanie primeneniya miliatsina dlya korrektsii immunosupressii, indutsirovannoj metotreksatom: avtoref. dis. … kand. med. nauk. Perm', 2010. 22s. [Zheleznova A. D. Experimental substantiation of the use of mieliacin for the correction of methotrexateinduced immunosuppression: author’s abstract. dis. … cand. med. sciences. Perm, 2010. 22 p.].

4. Kirillova A. V. Immunotropnaya aktivnost' miliatsina: avtoref. dis. … kand. med. Nauk. Perm', 2004. 25 s. [Kirillova A. V. Immunotropic activity of mieliacin: author’s abstract. dis. … cand. med. science. Perm, 2004. 25 p.].

5. Panfilova T. V. Protektivnaya aktivnost' miliatsina pri stressindutsirovannoj immunosupressii: avtoref. dis. … kand. med. nauk Perm', 2007. 23 s. [Panfi lova T. V. The protective activity of mieliacin in stress-induced immunosuppression: author’s abstract. dis. … cand. med. sciences of Perm, 2007. 23 c.].

6. Olifson L. E., Osadchaya N. D., Nuzov B. G., Galkovich K. G., Pavlova M. M. Khimicheskaya priroda i biologicheskaya aktivnost' miliatsina. Voprosy pitaniya 1991, 2, 57–59. [Oliphson L. E., Osadchaya N. D., Nuzov B. G., Galkovich K. G., Pavlova M. M. Chemical nature and biological activity of mieliacin. Questions of Nutrition 1991, 2, 57–59].

7. O’Toole G. A., Kolter R. Initiation of biofi lm formation in Pseudomonas fl uorescens WCS365 proceeds via multiple, convergent signalling pathways: a genetic analysis. Mol. Microbiol. 1998, 28 (3), 449–461.

8. Mittrucker H. W., Kohler A. A., Kaufmann S. H. Characterization of the murine T-lymphocyte response to Salmonella enteric serovar Typhimurium infection. Infect. Immun. 2002, 70, 199–203.

9. Cohen S. B. Crawley J. B., Kahan M. C. Interleukin-10 rescues T cells from apoptotic cell death: association with an upregulation of Bcl-2. Immunology 1997, 92 (1), 1–5.

10. Peck A., Mellins E. D., [et al.]..Plasticity of T-cell phenotype and function: the T helper type 17 example. Immunology 2010,129 (2), 147–153.

11. Manukhina E. B., Dauni Kh. F., Mallet R. T., Malyshev I. Yu. Zaschitnye i povrezhdayuschie ehffekty periodicheskoj gipoksii: rol' oksida azota. Vestnik rossijskoj AMN 2007, 2, 25–33. [Manukhina E. B., Downey H. F., Mallet R. T., Malyshev I. Yu. Protective and damaging eff ects of periodic hypoxia: the role of nitric oxide. Bulletin of the Russian Academy of Medical Sciences 2007, 2, 25–33].

12. Mosser D. M., Edwards J. P. Exploring the full of macrophage activation. Nature reviews Immunology 2008, 8(12), 958–969.

13. Kalinin V. I., Silchenko A. S., Avilov S., Stonik V. A., Smimov A. V. Sea cucumbers triterpene glycosides, the recent progress in structural elucidation and chemotaxonomy Phytochemistry Reviews 2005, 4, 221–236.

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