Dynamics of the functional status of neutrophilic granulocytes of urogenital secrets and neutrophiles allocated from the peripheral blood of women in various phase of the menstrual cycle

 
PIIS102872210002421-8-1
DOI10.31857/S102872210002421-8
Publication type Article
Status Published
Authors
Affiliation: South Ural state medical University
Journal nameRossiiskii immunologicheskii zhurnal
EditionVolume 12 Issue 3
Pages423-427
Abstract

The paper presents the results of analysis of the dynamics of the phagocytic reaction of neutrophils and the formation of extracellular DNA networks in the secrets of the urogenital tract and in the isolated pure fraction of neutrophilic granulocytes in the presence of cellular activators, depending on the phase of the menstrual cycle. It was found that the functional status of neutrophils in conditionally healthy women in the second half of the menstrual cycle is higher in comparison with the fi rst. This is probably due to increased reactivity of neutrophils with a more pronounced female hormonal profi le, which is observed in the second phase of the menstrual cycle and during pregnancy, which apparently plays an important role in protecting the urogenital tract of the pregnant woman and fetus.

Keywordsneutrophilic granulocytes, phagocytosis, extracellular DNA networks, HCT test
Received12.01.2019
Publication date12.01.2019
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