Dynamics of the functional status of neutrophilic granulocytes of urogenital secrets and neutrophiles allocated from the peripheral blood of women in various phase of the menstrual cycle

 
PIIS102872210002421-8-1
DOI10.31857/S102872210002421-8
Publication type Article
Status Published
Authors
Affiliation: South Ural state medical University
Journal nameRossiiskii immunologicheskii zhurnal
EditionVolume 12 Issue 3
Pages423-427
Abstract

The paper presents the results of analysis of the dynamics of the phagocytic reaction of neutrophils and the formation of extracellular DNA networks in the secrets of the urogenital tract and in the isolated pure fraction of neutrophilic granulocytes in the presence of cellular activators, depending on the phase of the menstrual cycle. It was found that the functional status of neutrophils in conditionally healthy women in the second half of the menstrual cycle is higher in comparison with the fi rst. This is probably due to increased reactivity of neutrophils with a more pronounced female hormonal profi le, which is observed in the second phase of the menstrual cycle and during pregnancy, which apparently plays an important role in protecting the urogenital tract of the pregnant woman and fetus.

Keywordsneutrophilic granulocytes, phagocytosis, extracellular DNA networks, HCT test
Received12.01.2019
Publication date12.01.2019
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1. Semenov B.F., Zverev V. V. Kontseptsiya sozdaniya bystroj immunologicheskoj zaschity ot patogenov. Zhurnal mikrobiologii, ehpidemiologii i immunobiologii 2007; 4: 93–100. [Semenov B. F., Zverev V. V. The concept of creating a rapid immunological defense against pathogens. Journal of Microbiology, Epidemiology and Immunobiology 2007; 4: 93–100].

2. Herant E. Mechanisms of neutrophil phagocytosis. Journal of cell science 2003;19: 45–50.

3. Skulachev V. P. Kislorod v zhivoj kletke: dobro i zlo, Sorosovskij obrazovatel'nyj zhurnal 1996; 2: 23–27 [Skulachev V. P. Oxygen in a living cell: good and evil, Soros Educational Journal 1996; 2: 23–27].

4. Halliwell B., Gutteridge J., Modulating A. Role for Antioxidants in Desiccation Tolerance/ Halliwell B. Biology 1998; l (45): 734–740.

5. Gol'dshtejn N. I. Aktivnye formy kisloroda kak zhiznenno neobkhodimye komponenty vozdushnoj sredy. Biokhimiya 2002; 67: 194–204. [Goldstein N. I. Active forms of oxygen as vital components of the air environment. Biochemistry 2002; 67: 194–204].

6. Delanty N., Dichter M. Oxidative injury in the nervous system. Acta Neurologica Scandinavica1998; 9: 145–153.

7. Savochkina A. Yu. Nejtrofil'nye vnekletochnye lovushki: mekhanizmy obrazovaniya, metody obnaruzheniya, biologicheskaya rol': dissertatsiya doktora meditsinskikh nauk. Chelyabinskaya gosudarstvennaya meditsinskaya akademiya. – Chelyabinsk, 2012. – 212c. [Savochkina A. Yu. Neutrophilic extracellular traps: mechanisms of formation, methods of detection, biological role. dis. MD, PhD, Chelyabinsk state medical Academy. – Chelyabinsk, 2012. –212 p.]

8. Brinkmann V., Zychlinsky V. Why neutrophils die to, make NETs. Nature 2007; 5: 577–582.

9. Smirnova T. G. Vliyanie zhenskikh polovykh steroidnykh gormonov na mekhanizm vnutri – i vnekletochnoj bakteritsidnosti fagotsitiruyuschikh kletok: dissertatsiya kandidata biologicheskikh nauk. Chelyabinskaya gosudarstvennaya meditsinskaya akademiya. – Chelyabinsk, 2014. –201c. [Smirnova T. G. The infl uence of female sex steroid hormones on the mechanisms of intra – and extracellular bacteriacidal activity of phagocytic cells: thesis PhD, Chelyabinsk state medical Academy.– Chelyabinsk, 2014.– 201p.].

10. Turpaev K. T. Aktivnye formy kisloroda i regulyatsiya ehkspressii genov. Biokhimiya 2002;3: 281–292. [Turpaev K. T. Active forms of oxygen and regulation of gene expression. Biochemistry 2002;3:281–292].

11. Mc.Cord J. M. Prevention of Neutrophil-Mediated Hepatic Ischemia. Reperfusion Injury by Superoxide Dismutase and Catalase Derivatives. The journal of pharmacology 1995; 34 (1): 231–243.

12. Oberley T. D., Toyokuni S., Szweda L. Localization of hydroxynonenal protein adducts in normal human kidney and selected human kidney cancers. Free Radic Biol Med 1999; 27(5–6): 695–703.

13. Beyrau M., Bodkin J. V, Nourshargh S. Neutrophil heterogen ity in health and disease: a revitalized avenue in infl ammation and immunity. Open Biol 2012; 2(11): 120–134.

14. Markova V. A. Sravnitel'nyj analiz funktsional'nykh svojstv nejtrofil'nykh granulotsitov perifericheskoj krovi i mukozal'nykh sekretov u zdorovykh muzhchin i zhenschin: dissertatsiya kandidata biologicheskikh nauk. Chelyabinskaya gosudarstvennaya meditsinskaya akademiya. – Chelyabinsk, 2014. –136 c. [Markova V. A. Comparative analysis of functional properties of neutrophilic granulocytes of peripheral blood and mucosal secretions in healthy men and women: thesis PhD, Chelyabinsk state medical Academy. – Chelyabinsk, 2014. –136 p.].

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