Subpopulation structure of T-lymphocytes in children with diff erent activity of juvenile idiopathic arthritis

 
PIIS102872210002416-2-1
DOI10.31857/S102872210002416-2
Publication type Article
Status Published
Authors
Affiliation:
Regional Children’s Clinical Hospital № 1
Institute of Immunology and Physiology, Urals Branch of the Russian Acad. Sci.
Journal nameRossiiskii immunologicheskii zhurnal
EditionVolume 12 Issue 3
Pages391-395
Abstract

Children of 6–17 years old with diff erent activity of juvenile idiopathic arthritis were examined: 74 with active arthritis and 14 with remission were treated with disease modifying therapy, 12 children with persistent remission and 32 apparently healthy children were without medications. The amount of CD3+, CD3+CD4+, CD3+CD8+, СD3+СD4–СD8–, СD3+СD4+СD8+, СD3+СD16/56+, СD3+СD4+СD25+СD127low/neg and СD3+СD4+СD25+СD127+ were investigated by fl ow cytometry. In all children with juvenile idiopathic arthritis the number regulatory T-cells (CD3+CD4+CD25+CD127low/neg) and double-positive lymphocytes (СD3+СD4+СD8+) was decreased. The amount of NKT (СD3+СD16/56+) in patients with active arthritis and with remission was too decreased.

Keywordsjuvenile idiopathic arthritis, lymphocytes, fl ow cytometry
AcknowledgmentThe work was performed as part of the state assignment of IIF UB RAS (R & D number of the research and development department No. AAAA-A18–118020590108–7).
Received11.01.2019
Publication date12.01.2019
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