Subpopulation structure of T-lymphocytes in children with diff erent activity of juvenile idiopathic arthritis

Children of 6–17 years old with diff erent activity of juvenile idiopathic arthritis were examined: 74 with active arthritis and 14 with remission were treated with disease modifying therapy, 12 children with persistent remission and 32 apparently healthy children were without medications. The amount of CD3+, CD3+CD4+, CD3+CD8+, СD3+СD4–СD8–, СD3+СD4+СD8+, СD3+СD16/56+, СD3+СD4+СD25+СD127low/neg and СD3+СD4+СD25+СD127+ were investigated by fl ow cytometry. In all children with juvenile idiopathic arthritis the number regulatory T-cells (CD3+CD4+CD25+CD127low/neg) and double-positive lymphocytes (СD3+СD4+СD8+) was decreased. The amount of NKT (СD3+СD16/56+) in patients with active arthritis and with remission was too decreased.

Keywords

juvenile idiopathic arthritis, lymphocytes, fl ow cytometry

Acknowledgment

The work was performed as part of the state assignment of IIF UB RAS (R & D number of the research and development department No. AAAA-A18–118020590108–7).

Received

11.01.2019

Publication date

12.01.2019

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GOST	Pashnina I. Subpopulation structure of T-lymphocytes in children with diff erent activity of juvenile idiopathic arthritis // Rossiiskii immunologicheskii zhurnal – 2018. – V. 12. – Issue 3 C. 391-395 [Electronic resource]. URL: http://ras.jes.su/ruimm/s207987840001610-0-1-en (circulation date: 19.04.2024). DOI: 10.31857/S102872210002416-2
MLA	Pashnina, I. "Subpopulation structure of T-lymphocytes in children with diff erent activity of juvenile idiopathic arthritis." Rossiiskii immunologicheskii zhurnal 12.3 (2018):391-395. DOI: 10.31857/S102872210002416-2
APA	Pashnina I. (2018). Subpopulation structure of T-lymphocytes in children with diff erent activity of juvenile idiopathic arthritis. Rossiiskii immunologicheskii zhurnal 12(3), pp.391-395 DOI: 10.31857/S102872210002416-2

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