Analysis of subpopulation composition of Th-lymphocytes in peripheral blood in women with miscarriage

 
PIIS102872210002409-4-1
DOI10.31857/S102872210002409-4
Publication type Article
Status Published
Authors
Affiliation: South-Ural State Medical University
Affiliation: South-Ural State Medical University
Journal nameRossiiskii immunologicheskii zhurnal
EditionVolume 12 Issue 3
Pages354-357
Abstract

The results of the study of the analysis of the subpopulation composition of Th-lymphocytes in peripheral blood in women with miscarriage. The peripheral venous blood of the subjects served as a material for the study. The determination of T-lymphocytes (CD3+CD4+) and their subpopulations (Th1, Th2, Th17, Th17 / Th1) was performed by fl ow cytometry. It was found that the level of Th1, Th2, Th17 and Th17 / Th1 in peripheral blood in women with miscarriage is higher in comparison with the group of conditionally healthy women with two or more successful pregnancies in pairs with the same partner, which is associated with increased reactivity of the immune system (in particular, the cellular unit) in relation to the semialogenic fetus.

Keywordsmiscarriage, Th1, Th2, Th17, Th17/Th1
Received11.01.2019
Publication date12.01.2019
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