Study of migration of nano-dimensional metallic particles in the composition of supernatants on the model of inbreed mobiles BALB-CJ

 
PIIS102872210002407-2-1
DOI10.31857/S102872210002407-2
Publication type Article
Status Published
Authors
Affiliation: Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
Affiliation: Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
Affiliation: The Institute of Mitoengineering of Lomonosov Moscow State University
Affiliation: Institute of Bioorganic Chemistry named by Academicians M.M. Shemyakin and Y.A. Ovchinnikov
Affiliation: Institute of Bioorganic Chemistry named by Academicians M.M. Shemyakin and Y.A. Ovchinnikov
Affiliation: FNKTS children’s hematology, oncology and immunology D. Rogachev
Journal nameRossiiskii immunologicheskii zhurnal
EditionVolume 12 Issue 3
Pages342-347
Abstract

The purpose of this study was to investigate the ability of migration into the immunocompetent organs of nanoscale metal particles in the composition of supernatants. The goal is to model peritonitis, with intraperitoneal administration of solutions, in particular, with induction and without induction by lipopolysaccharide. Nanoscale metal particles were obtained in the laboratory from the surface of the dental implants “Nobel Biocare” and “Alpha BiO” in the composition of supernatants. In the experiment, 12 inbred mice, divided conditionally into 3 groups were injected with solutions: antibiotic, nanoscale particles obtained from two systems of dental implants in supernatants. On day 10 three organs were examined: the liver, kidney and spleen. A histological study indicated the presence of Al2O3, nanoparticles, found on the boundary between white and red pulp inside macrophages in the group injected with supernatants taken from «Alpha BIO» surface.

Keywordsnanoscale metal particles, mouse model, aseptic peritonitis, spleen
Received11.01.2019
Publication date12.01.2019
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