Features of the infectious process in patients with HPV-associated ectopia of the cervix uteri

The work is devoted to the evaluation of the role of factors of innate immunity in cervical ectopy associated with papillomavirus infection. All women underwent viral load determination and genotyping of human papillomavirus (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 types) by real-time PCR. The study of the cytokine profi le (IL 1β, RAIL-1, IL-2, IL-4, IL-8, IL-10, TNF-α, IF-α, IF-γ) and neutrophilic immunity of cervical mucus in women with ectopia of the cervix, associated with the human papillomavirus of oncogenic risk. According to the results of the study, a wide spectrum of oncogenic types of human papillomavirus was identifi ed, among which the highly aggressive type 16 was the leader. In 28.95% of cases, infection was detected by several types of the virus, and in 74.93% of cases, signifi cant and increased viral load was detected. Changes in the functional capacity of neutrophils of cervical mucus consisted in a signifi cant decrease in phagocytic reaction, oxygen-dependent metabolism, expressed in inhibition of activity and intensity of spontaneous and induced NST-tests in comparison with similar parameters of the control group.

Keywords

human papilloma virus, cervical ectopia, cytokines, neutrophils, viral load

Received

11.01.2019

Publication date

12.01.2019

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GOST	Zotova M., Nikushkina K., Mezentseva E., Baturina I., Loginova Y., Samuseva I., Smirnova T., Nikonova T., Gromakova K. Features of the infectious process in patients with HPV-associated ectopia of the cervix uteri // Rossiiskii immunologicheskii zhurnal – 2018. – V. 12. – Issue 3 C. 311-316 [Electronic resource]. URL: http://ras.jes.su/ruimm/s207987840001596-4-1-en (circulation date: 20.04.2025). DOI: 10.31857/S102872210002401-6
MLA	Zotova, M., Nikushkina, K., Mezentseva, E., Baturina, I., Loginova, Yu, Samuseva, I., Smirnova, T., Nikonova, T., Gromakova, K. "Features of the infectious process in patients with HPV-associated ectopia of the cervix uteri." Rossiiskii immunologicheskii zhurnal 12.3 (2018):311-316. DOI: 10.31857/S102872210002401-6
APA	Zotova M., Nikushkina K., Mezentseva E., Baturina I., Loginova Y., Samuseva I., Smirnova T., Nikonova T., Gromakova K. (2018). Features of the infectious process in patients with HPV-associated ectopia of the cervix uteri. Rossiiskii immunologicheskii zhurnal 12(3), pp.311-316 DOI: 10.31857/S102872210002401-6

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