Features of the infectious process in patients with HPV-associated ectopia of the cervix uteri

 
PIIS102872210002401-6-1
DOI10.31857/S102872210002401-6
Publication type Article
Status Published
Authors
Affiliation: South-Ural State Medical University
Affiliation: South-Ural State Medical University
Affiliation: South-Ural State Medical University
Affiliation: South-Ural State Medical University
Affiliation: South-Ural State Medical University
Affiliation: South-Ural State Medical University
Affiliation: South-Ural State Medical University
Affiliation: South-Ural State Medical University
Affiliation:
South-Ural State Medical University
Chelyabinsk State University
Journal nameRossiiskii immunologicheskii zhurnal
EditionVolume 12 Issue 3
Pages311-316
Abstract

The work is devoted to the evaluation of the role of factors of innate immunity in cervical ectopy associated with papillomavirus infection. All women underwent viral load determination and genotyping of human papillomavirus (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 types) by real-time PCR. The study of the cytokine profi le (IL 1β, RAIL-1, IL-2, IL-4, IL-8, IL-10, TNF-α, IF-α, IF-γ) and neutrophilic immunity of cervical mucus in women with ectopia of the cervix, associated with the human papillomavirus of oncogenic risk. According to the results of the study, a wide spectrum of oncogenic types of human papillomavirus was identifi ed, among which the highly aggressive type 16 was the leader. In 28.95% of cases, infection was detected by several types of the virus, and in 74.93% of cases, signifi cant and increased viral load was detected. Changes in the functional capacity of neutrophils of cervical mucus consisted in a signifi cant decrease in phagocytic reaction, oxygen-dependent metabolism, expressed in inhibition of activity and intensity of spontaneous and induced NST-tests in comparison with similar parameters of the control group.

Keywordshuman papilloma virus, cervical ectopia, cytokines, neutrophils, viral load
Received11.01.2019
Publication date12.01.2019
Cite   Download pdf To download PDF you should sign in
Размещенный ниже текст является ознакомительной версией и может не соответствовать печатной

views: 1040

Readers community rating: votes 0

1. Rusakevich P. S., Fokina P. S. Ehktopii shejki matki (sovremennoe sostoyanie problemy). Okhrana materinstva i detstva 2006, 1–7, 88–93. [Rusakevich P. S., Fokina P. S. Ectopias of the cervix (current state of the problem). Protection of motherhood and childhood 2006, 1–7, 88–93].

2. Olina A. A., Padrul' V. M. Mestnyj immunitet i lokal'naya immunoterapiya ehktopii shejki matki. Zhurnal akusherstva i zhenskikh boleznej 2006, LV(4), 71–76. [Olina A. A., Padrul V. M. Local immunity and local immunotherapy of cervical ectopy. Journal of Obstetrics and Women’s Diseases 2006, LV, 4, 71–76].

3. Manynbaev O. A., Eliseeva M. Yu., Doorbar Dzh., Manukhin I. B. Ehpidemiologiya, molekulyarnaya biologiya, patofiziologiya i printsipy immunoterapii PVI. Voprosy ginekologii, akusherstva i perinatologii 2009, 8, 3, 69–79. [Mannybaev O. A., Eliseeva M. Yu., Doorbar J., Manukhin I. B. Epidemiology, molecular biology, pathophysiology and principles of immunotherapy of PVI. Questions of gynecology, obstetrics and perinatology 2009, 8 (3), 69–79].

4. Privalova M. A. Izmeneniya mestnogo immuniteta pri vospalitel'nykh zabolevaniyakh zhenskikh polovykh organov. Vestnik novykh meditsinskikh tekhnologij 2008, XV(2), 55–56. [Privalova M. A. Changes in local immunity in infl ammatory diseases of female genital organs. Bulletin of New Medical Technologies 2008, XV(2), 55–56.]

5. Dolgushin I. I., Bukharin O. V. Nejtrofily i gomeostaz. V kn.: Nejtrofily i gomeostaz. UrO RAN, Ekaterinburg 2001, 282 s. [Dolgushin I. I., Bukharin O. V. Neutrophils and homeostasis. In the book .: Neutrophils and homeostasis. Ural Branch of the Russian Academy of Sciences, Ekaterinburg 2001, 282 p.].

6. Zhang X., Kluger Y., Nakayama Y. Gene expression in mature neutrophils: early responses to infl ammatory stimuli. J. Leukoc. Biol. 2004, Vol.75, № 2, 358–372.

7. Dolgushin I. I., Andreeva Yu. S., Savochkina A. Yu. Nejtrofil'nye vnekletochnye lovushki i metody otsenki funktsional'nogo statusa nejtrofilov. Izdatel'stvo RAMN, Moskva 2009, 208s. [Dolgushin I. I., Andreeva Yu.S., Savochkina A. Yu. Neutrophil extracellular traps and methods for assessing the functional status of neutrophils. Publishing house of RAMS, Moscow 2009, 208 p.].

8. Nesterova I. V. Fiziologicheskaya rol' nejtrofil'nykh granulotsitov v podderzhanii immunnogo gomeostaza. Ross. immun. Zhurnal 2004, 9, Prilozhenie 1, 17. [Nesterova I. V. The physiological role of neutrophilic granulocytes in the maintenance of immune homeostasis. Ross. immun. Journal 2004, 9, Appendix 1, 17].

9. Shvydchenko I. N., Nesterova I. V., Sinel'nikova E. Yu. Tsitokinsekretiruyuschaya funktsiya nejtrofil'nykh granulotsitov. Immunologiya 2005, 1, 31–34.[Shvydchenko I.N., Nesterova I. V., Sinelnikova E. Yu. Cytokine secreting function of neutrophilic granulocytes. Immunology 2005, 1, 31–34].

10. Denkers E. Y., Del Rio L., Bennouna S. Neutrophil production of IL-12 and other cytokines during microbal infection. Chem.Immunol. Allergy 2003, 83, 95–114.

11. Simbirtsev A. S. Tsitokiny – novaya sistema regulyatsii zaschitnykh reaktsij organizma. Tsitokiny i vospalenie 2002, 1, 125–126. [Simbirtsev A. S. Cytokines are a new system of regulation of the body’s defense responses. Cytokines and infl ammation 2002, 1, 125–126].

Система Orphus

Loading...
Up