Impact on ceruloplasmin on the chemiluminescence of neutrophils in chronic submaximal exercise capacity

Exercise simulated in an experiment on 59 white rats. Chronic physical load submaximal power modeled daily swimming for 30 minutes. The load was increased gradually: the fi rst seven days, the animals swam every day without a load, the next two weeks the animals swam with a load of 2% of body weight. On 9, 15 and 21 day of the experiment, the animals were subjected to an additional maximum exertion: swam for 4 minutes with a load weight of 20% of body weight. Blood sampling was carried out on 9, 15 and 21 days after the experiment exercise intracardiac. Ceruloplasmin was administered on the 1st, 4th and 7th day of physical activity, in a total dose of 60 mg / kg of body weight. The intensity of free radical oxidation in whole blood was investigated by luminol-enhanced chemiluminescence. Under experimental conditions in rats, it was shown that in the case of chronic physical exercise of submaximal power, the production of free radicals in neutrophils decreases. The introduction of ceruloplasmin does not lead to a reduction in the reduced production of free radicals by neutrophilic leukocytes during physical activity.

Keywords

physical activity, free radical oxidation, ceruloplasmin, chemiluminescence

Received

23.11.2018

Publication date

12.01.2019

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GOST	Ermolaeva E., Kantyukov S., Petuhova V., Surina-Marysheva E. Impact on ceruloplasmin on the chemiluminescence of neutrophils in chronic submaximal exercise capacity // Rossiiskii immunologicheskii zhurnal – 2018. – V. 12. – Issue 3 C. 281-285 [Electronic resource]. URL: http://ras.jes.su/ruimm/s207987840001590-8-1-en (circulation date: 26.01.2025). DOI: 10.31857/S102872210002395-9
MLA	Ermolaeva, E., Kantyukov, S., Petuhova, V., Surina-Marysheva, E. "Impact on ceruloplasmin on the chemiluminescence of neutrophils in chronic submaximal exercise capacity." Rossiiskii immunologicheskii zhurnal 12.3 (2018):281-285. DOI: 10.31857/S102872210002395-9
APA	Ermolaeva E., Kantyukov S., Petuhova V., Surina-Marysheva E. (2018). Impact on ceruloplasmin on the chemiluminescence of neutrophils in chronic submaximal exercise capacity. Rossiiskii immunologicheskii zhurnal 12(3), pp.281-285 DOI: 10.31857/S102872210002395-9

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