Impact on ceruloplasmin on the chemiluminescence of neutrophils in chronic submaximal exercise capacity

Exercise simulated in an experiment on 59 white rats. Chronic physical load submaximal power modeled daily swimming for 30 minutes. The load was increased gradually: the fi rst seven days, the animals swam every day without a load, the next two weeks the animals swam with a load of 2% of body weight. On 9, 15 and 21 day of the experiment, the animals were subjected to an additional maximum exertion: swam for 4 minutes with a load weight of 20% of body weight. Blood sampling was carried out on 9, 15 and 21 days after the experiment exercise intracardiac. Ceruloplasmin was administered on the 1st, 4th and 7th day of physical activity, in a total dose of 60 mg / kg of body weight. The intensity of free radical oxidation in whole blood was investigated by luminol-enhanced chemiluminescence. Under experimental conditions in rats, it was shown that in the case of chronic physical exercise of submaximal power, the production of free radicals in neutrophils decreases. The introduction of ceruloplasmin does not lead to a reduction in the reduced production of free radicals by neutrophilic leukocytes during physical activity.

Keywords

physical activity, free radical oxidation, ceruloplasmin, chemiluminescence

Received

23.11.2018

Publication date

12.01.2019

Cite Download pdf To download PDF you should sign in

GOST	Ermolaeva E., Kantyukov S., Petuhova V., Surina-Marysheva E. Impact on ceruloplasmin on the chemiluminescence of neutrophils in chronic submaximal exercise capacity // Rossiiskii immunologicheskii zhurnal – 2018. – V. 12. – Issue 3 C. 281-285 [Electronic resource]. URL: http://ras.jes.su/ruimm/s207987840001590-8-1-en (circulation date: 26.04.2024). DOI: 10.31857/S102872210002395-9
MLA	Ermolaeva, E., Kantyukov, S., Petuhova, V., Surina-Marysheva, E. "Impact on ceruloplasmin on the chemiluminescence of neutrophils in chronic submaximal exercise capacity." Rossiiskii immunologicheskii zhurnal 12.3 (2018):281-285. DOI: 10.31857/S102872210002395-9
APA	Ermolaeva E., Kantyukov S., Petuhova V., Surina-Marysheva E. (2018). Impact on ceruloplasmin on the chemiluminescence of neutrophils in chronic submaximal exercise capacity. Rossiiskii immunologicheskii zhurnal 12(3), pp.281-285 DOI: 10.31857/S102872210002395-9

Размещенный ниже текст является ознакомительной версией и может не соответствовать печатной

Readers community rating: votes 0

1. Panyushkin V. V., Rozhkov E. A., Tulova E. A. et al. Mechanisms of limiting physical performance hemodynamic disorders in microcirculation link. Bulletin of Sport Science, 2013, (2), 25–30.

2. Pesic S., Jakovljevic V., Djordjevic D. et al. Exerciseinduced changes in redox status of elite karate athletes. Chin J Physiol, 2012, 55 (1), 8–15.

3. Surina-Marysheva E. F., Krivokhizhina L. V., Kantyukov S. A. et al. Eff ect of ceruloplasmin on the number and resistance of erythrocytes in acute physical exertion. Bulletin of Experimental Biology and Medicine, 2009, 148(8), 151–153. Russian

4. Farkhutdinov R. R., Likhovsky V. A. Chemiluminescent methods for studying free radical oxidation in biology and medicine, Ufa: Izdatelstvo BGMI, 1995, 90. Russian

5. Heinonen I., Kemppainen J., Kaskinoro K. et al. Eff ects of adenosine, exercise, and moderate acute hypoxia on energy substrate utilization of human skeletal muscle. Am J Physiol Regul Integr Comp Physiol, 2012, 302(3), 385–390.

6. Little J. P., Safdar A., Wilkin G. P. et al. A practical model of low-volume high-intensity interval training induces mitochondrial biogenesis in human skeletal muscle: potential mechanisms. J Physiol, 2010, 588 (6), 1011–1022.

7. Finaud J., Scislowski V., Lac G., Durand D. et al. Antioxidant status and oxidative stress in professional rugby players: evolution throughout a season. Int J Sports Med, 2006, 27(2), 87–93.

8. Silva L. A., Silveira P. C. L., Ronsani M. M. et al. Taurine supplementation decreases oxidative stress in skeletal muscle after eccentric exercise. Cell biochemistry and function, 2011, 29(1), 43–49.

9. Powers S. K., Talbert E. E., Adhihetty P. J. Reactive oxygen and nitrogen species as intracellular signals in skeletal muscle. J. Physiol, 2011, 589 (9), 2129–2138.

10. Powers S. K., Talbert E. E., Adhihetty P. J. Reactive oxygen and nitrogen species as intracellular signals in skeletal muscle. J. Physiol, 2011, 589 (9), 2129–2138.

11. Kantyukov S.A., Ermolaeva E.N., Krivokhizhina L.V. Free radical oxidation in whole blood during physical exertions of various duration and intensity. Modern problems of science and education, 2015, 6: URL: www.science-edication.ru/130–23081 Russian

12. Mzhelskaya T. I. Biological functions of ceruloplasmin and their defi - ciency in mutations of genes that regulate the exchange of copper and iron. Bulletin of Experimental Biology and Medicine, 2000, 130(8), 124–133. Russian

13. Ermolaeva E. N., Krivokhizhina L. V. Ceruloplasmin in correction of dyslipidemia caused by chronic physical exercise of submaximal power in the experiment. Experimental and Clinical Pharmacology, 2016, 79(6), 9–11. Russian

14. Vashchenko V. I., Vaschenko T. N. Ceruloplasmin: from the metabolite to the drug. Psychopharmacology and biological narcology, 2006, 6(3), 1254–1269. Russian