The network interaction of the neurocytocine system in the context of social adaptation of children with autism spectrum disorders

The paper presents the results of the study of neurocytokine interactions in children with autism spectrum disorders with diff erent levels of social adaptation. Two excellent images of functional networks were revealed: in the group “ASD, social contact” – a network with a small number of correlation links – “image of delayed neurodevelopment”; in the group “ASD, without social contact” – the network of correlations is tense, indicating the activation of the sympathetic-adrenal axis, which is the base in the adaptation reaction “fi ght/ fl ight” or “frozen behavior” – the image of the “closed system”.

Keywords

cytokines, neurohormones, children, autism spectrum disorders

Received

22.11.2018

Publication date

12.01.2019

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GOST	Burmistrova A., Filippova Y., Timofeeva A. The network interaction of the neurocytocine system in the context of social adaptation of children with autism spectrum disorders // Rossiiskii immunologicheskii zhurnal – 2018. – V. 12. – Issue 3 C. 227-232 [Electronic resource]. URL: http://ras.jes.su/ruimm/s207987840001581-8-1-en (circulation date: 18.02.2025). DOI: 10.31857/S102872210002386-9
MLA	Burmistrova, A., Filippova, Yu, Timofeeva, A. "The network interaction of the neurocytocine system in the context of social adaptation of children with autism spectrum disorders." Rossiiskii immunologicheskii zhurnal 12.3 (2018):227-232. DOI: 10.31857/S102872210002386-9
APA	Burmistrova A., Filippova Y., Timofeeva A. (2018). The network interaction of the neurocytocine system in the context of social adaptation of children with autism spectrum disorders. Rossiiskii immunologicheskii zhurnal 12(3), pp.227-232 DOI: 10.31857/S102872210002386-9

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1. Di Cicco-Bloom E., Lord C., Zwaigenbaum L., Cour chesne E., Dager S. R., Schmitz C., Schultz R. T., Crawley J., Young L. J. The developmental neurobiology of autism spectrum disorder. J. Neurosci., 2006, 26(26), 6897–6096

2. Baron-Cohen S. Editorial Perspective: Neurodiversity – a revolutionary concept for autism and psychiatry. J. Child. Psychol. Psychiatry, 2017, 58(6), 744–747

3. Skuse D. H., Gallagher L. Dopaminergic-neuropeptide interactions in the social brain. Trends Cogn. Sci., 2008, 13(1), 27–35.

4. Porges S. W. The polyvagal perspective. Bio. Psychol., 2007, 74(2), 116–143

5. Klein J. T., Shepherd S. V., Platt M. L. Social attention and the brain. Curr. Biol., 2009, 19(20), 958–962

6. Rizzolatti G., Craighero L. The mirror-neuron system. Annu. Rev. Neurosci., 2004, 27, 169–192.

7. Adolphs R. Is the human amygdala specialized for processing social information? Ann. N. Y. Acad. Sci., 2003, 985, 326–340.

8. Kirsch P., Esslinger C., Chen Q., Mier D., LisvS., Siddhanti S., Gruppe H., Mattay V. S., Gallhofer B., Meyer- Lindenberg A. Oxytocin modulates neural circuitry for social cognition and fear in humans. J. Neurosci., 2005, 25 (49, 11489–11493.)

9. Guastella A. J., Mitchell P. B., Dadds M. R. Oxytocin increases gaze to the eye region of human faces. Biol. Psychiatry, 2008, 63 (1), 3–5.

10. Campbell A. Attachment, aggression and affi liation: the role of oxytocin in female social behavior.Biol. Psychol., 2008, 77 (1), 1–10

11. Naglova H., Bucova M. HMGB1 and its physiological and pathological roles. Bratisl. Lek. Listy., 2012, 113(3), 163–171.

12. Goldstein D. S., Eisenhofer G., Kopin I. J. Sources and signifi cance of plasma levels of catechols and ther metabolites in humans. J. Pharmacol. Exp. Ther., 2003, 305 (3), 800–811.

13. Baskerville T. A., Douglas A. J. Dopamine and oxytocin interactions underlying behaviors: potential contributions to behavioral disorders. CNS Neurosci. Ther., 2010, 16(3), 92–123.

14. Cunningham E. T. Jr., De Souza E. B. Interleukin 1 receptor in the brain and endocrine tissue. Immunol. Today, 1993, 14(4), 171–176.

15. Goshen I., Yirmiva R. Interleukin-1 (IL-1): a central regulator of stress responses. Front. Neuroendocrinol., 2009, 30(1), 30–45.

16. Ferguson B. J., Marler S., Altstein L. L. et al. Associations between cytokines, endocrine stress response, and gastrointestinal symptoms in autism spectrum disorder. Brain Behav. Immun., 2016, 58, 57–62.