Features of the cytokine profile and relationships of polymorphisms of the immune system with levels of serum cytokines in individuals exposed to chronic radiation exposure

Publication type Article
Status Published
Urals Research Center for Radiation Medicine of the FMBA of Russia
Southern-Urals State Medical University of the RF Ministry of Public Health
Urals Research Center for Radiation Medicine of the FMBA of Russia
Chelyabinsk State University
Affiliation: Urals Research Center for Radiation Medicine of the FMBA of Russia
Journal nameRossiiskii immunologicheskii zhurnal
EditionVolume 12 Issue 3

The article presents the results of the cytokine profi le study in Techa riverside residents exposed to chronic irradiation in diff erent periods of ontogenesis, as well as the relationship of the carrier polymorphic variants of genes IL1b, IL2, IL4, IL6, IL8 and TNFα with the content of the corresponding cytokines in the blood serum of irradiated persons. The decrease in the levels of pro-infl ammatory (IL-1β, IL-2, IL-6) and anti-infl ammatory (IL-4, IL-10) cytokines was noted in Techa riverside residents, whose period of intrauterine and childhood development fell out on the time of maximum radioactive discharges relative to groups of persons irradiated only in the postnatal period. Also, the connection of polymorphic rs1800872 gene IL10 with IL-10 content in blood serum was revealed.

Keywordsradiation, cytokines, genes, polymorphism
Publication date12.01.2019
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