CD57 expression by peripheral blood cytotoxic T cells in sarcoidosis

Using 10-color fl ow cytometry we characterized cytotoxic T cell subsets based on expression of CD45RA, CD62L, CD27, and CD28 and compared the expression of CD57 between these subsets in peripheral blood sample from patients with chronic sarcoidosis (n=46) and healthy volunteers (n=46). Circulating naive, central and eff ector memory as well as TEMRA CD3+CD8+ cells of sarcoidosis patients contained signifi cantly increased proportions CD57+ cells when compared with healthy controls. Interestingly, CD57 expression was increased in subsets with ‘non mature’ and intermediate phenotypes – EM1, EM2, EM4, pE1 and pE2. Our results indicate the involvement of CD3+CD8+ in maintenance in sarcoidosis as well as suggest CD57-positive cells to be the novel target for evaluation the eff ectiveness of sarcoidosis therapy.

Keywords

sarcoidosis, cytotoxic T cells, CD57 expression, fl ow cytometry

Received

11.01.2019

Publication date

12.01.2019

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GOST	Kudryavtsev I., Lazareva N., Baranova O., Serebriakova M., Ses’ T., Ilkovich M., Totolyan A. CD57 expression by peripheral blood cytotoxic T cells in sarcoidosis // Rossiiskii immunologicheskii zhurnal – 2018. – V. 12. – Issue 3 C. 329-334 [Electronic resource]. URL: http://ras.jes.su/ruimm/s207987840001599-7-1-en (circulation date: 18.03.2025). DOI: 10.31857/S102872210002405-0
MLA	Kudryavtsev, I., Lazareva, N., Baranova, O., Serebriakova, M., Ses’, T., Ilkovich, M., Totolyan, A. "CD57 expression by peripheral blood cytotoxic T cells in sarcoidosis." Rossiiskii immunologicheskii zhurnal 12.3 (2018):329-334. DOI: 10.31857/S102872210002405-0
APA	Kudryavtsev I., Lazareva N., Baranova O., Serebriakova M., Ses’ T., Ilkovich M., Totolyan A. (2018). CD57 expression by peripheral blood cytotoxic T cells in sarcoidosis. Rossiiskii immunologicheskii zhurnal 12(3), pp.329-334 DOI: 10.31857/S102872210002405-0

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