Immunological features of reactive arthritis depending on the inflammatory activity

 
PIIS102872210002397-1-1
DOI10.31857/S102872210002397-1
Publication type Article
Status Published
Authors
Affiliation: Orenburg State Medical University
Journal nameRossiiskii immunologicheskii zhurnal
EditionVolume 12 Issue 3
Pages290-294
Abstract

The analysis of the immune status in 150 patients with reactive arthritis (ReA) depending on the infl ammatory activity of the disease was carried out. A statistically signifi cant inhibition of T-dependent reactions (CD3+-, CD8+- and CD4+), inhibition of neutrophil phagocytic activity, increase in blood proinfl ammatory cytokines (TNF-α, IFN-γ, IL-8) is directly proportional to the increase in the degree of disease activity. Increased content of CD20+, CIC, IgA and Ig M. There is an imbalance of cytokines and the dependence of their concentrations on the degree of infl ammatory activity of ReA, with an increase in which the content of IL-6, TNF-α, IFN-γ increases in direct proportion, which should be taken into account in the therapy.

Keywordsreactive arthritis, immunological features, activity
Received23.11.2018
Publication date12.01.2019
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