Impact of subcutaneus allergenspecifi c immunotherapy on the level of cytokines in nazal secretions of children with combined forms of respiratory pollene allergy

Emelina, Yu.; Zurochka, A.

doi:10.31857/S102872210002393-7

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Rossiiskii immunologicheskii zhurnal

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Impact of subcutaneus allergenspecifi c immunotherapy on the level of cytokines in nazal secretions of children with combined forms of respiratory pollene allergy

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Impact of subcutaneus allergenspecifi c immunotherapy on the level of cytokines in nazal secretions of children with combined forms of respiratory pollene allergy

PII

S102872210002393-7-1

DOI

10.31857/S102872210002393-7

Publication type

Article

Status

Published

Authors

Yu. Emelina

Affiliation: Regional Children’s clinical Hospital № 1

A. Zurochka

Affiliation:
Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences
South Ural State University (National Research University)

Journal name

Rossiiskii immunologicheskii zhurnal

Edition

Volume 12 Issue 3

Pages

268-275

Abstract

In children with concomitant respiratory forms of pollen allergy after three courses of the subcutaneous immunotherapy in nasal secretions investigated levels of G-CSF, GM–CSF, IL-10, IL-12p70, INF-gamma, IL-13, IL-17A, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, TNF-alpha, IL-8, MCP-1, MIP-1β. Children with combined forms of respiratory allergy to pollen trees in remission of allergic disease at the local epitope (in the nasal mucosa) had signs of chronic infl ammatory process with violation of the immune response by increasing the synthesis of pro- and decreased of production anti-infl ammatory cytokines and gain of reactions aimed at elimination of the allergen. After the subcutaneous immunotherapy showed reduction index IL-1β/INF-¬, IL-1β/IL-4, IL-1β/IL-12 and MIP-1β/IL-12.

Keywords

cytokines, indices of the ratio of cytokines, subcutaneous allergen-specifi c immunotherapy

Received

23.11.2018

Publication date

12.01.2019

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GOST	Emelina Y., Zurochka A. Impact of subcutaneus allergenspecifi c immunotherapy on the level of cytokines in nazal secretions of children with combined forms of respiratory pollene allergy // Rossiiskii immunologicheskii zhurnal – 2018. – V. 12. – Issue 3 C. 268-275 [Electronic resource]. URL: http://ras.jes.su/ruimm/s207987840001588-5-1-en (circulation date: 20.04.2024). DOI: 10.31857/S102872210002393-7
MLA	Emelina, Yu, Zurochka, A. "Impact of subcutaneus allergenspecifi c immunotherapy on the level of cytokines in nazal secretions of children with combined forms of respiratory pollene allergy." Rossiiskii immunologicheskii zhurnal 12.3 (2018):268-275. DOI: 10.31857/S102872210002393-7
APA	Emelina Y., Zurochka A. (2018). Impact of subcutaneus allergenspecifi c immunotherapy on the level of cytokines in nazal secretions of children with combined forms of respiratory pollene allergy. Rossiiskii immunologicheskii zhurnal 12(3), pp.268-275 DOI: 10.31857/S102872210002393-7

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