Immunobiochemical markers of the gematoentsefalitics barrier and autosensibilization at early forms chronic ischemia of the brain

Publication type Article
Status Published
South Ural State Medical University
Chelyabinsk Regional Clinical Hospital
South Ural State University (National Research University)
Federal State Institution of Science Institute of Immunology and Physiology
South Ural State Medical University
Chelyabinsk Regional Clinical Hospital
Journal nameRossiiskii immunologicheskii zhurnal
EditionVolume 12 Issue 3

The level of neurospecifi c proteins and autoantibodies to the subunit NR2 of the NMDA receptor in veterans with early forms of chronic cerebral ischemia was studied. It was shown that these patients had permeability disturbances of the blood-brain barrier with the growth of autosensibilization processes to brain antigens, which may be one of the mechanisms of progression of chronic cerebral ischemia and a predicted failure of cerebral circulation compensation in patients with progressive course of chronic cerebral ischemia. On the other hand, the defi nition of neurospecifi c proteins in the systemic circulation may be promising for the diagnosis of early stages of chronic cerebral ischemia, when other objective methods of research may be of little informative.

Keywordsearly forms of chronic cerebral ischemia, neurospecifi c proteins, autoantibodies to subunit of NR2 NMDA receptor
Publication date12.01.2019
Cite   Download pdf To download PDF you should sign in
Размещенный ниже текст является ознакомительной версией и может не соответствовать печатной

views: 1114

Readers community rating: votes 0

1. Shmidt Ye. V. Classifi cation of vascular damages of a head and spinal cord / E.V. Schmidt// Journalofneuropathology and psychiatry. 1985, 9, 1281–1288. Russian

2. R. H. Dyck, I. I. Bogoch, A. Marks, [et al.] Enhanced epileptogenesis in S100B knockout mice / // Brain Res. Mol. Brain Res. 2002. Vol. 106. P. 22–29.

3. P. M. Bokesch, G. A. Izykenova, J. B. Justice, [et al.] NMDA receptor antibodies predict adverse neurological outcome after cardiac surgery in high-risk patients. // Stroke. 2006. Vol. 37. P. 1432–1436.

4. Davydova E. V. Defi nition was autoantitels to a subunitsof NR2 of a glutamate receptor of NMDA at veterans of Afghanistan with early forms of chronic ischemia of a brain / E. V. Davydova // Russian journal of immunology. 2016, 10 (19), 3, 241–243. Russian

5. J. D. Weissman, G. A. Khunteev, R. Heath, [et al.] NR2 antibodies: risk assessment of transient ischemic attack (TIA)/stroke inpatients with history of isolated and multiple cerebrovascular events // J. Neurol Sci. 2011, 300,1–2, 97–102.

Система Orphus