The role of mielopeptides MP-5 and MP-6 in regulation of the functional activity of peritoneal macrophages under immobilizational stress

 
PIIS102872210002387-0-1
DOI10.31857/S102872210002387-0
Publication type Article
Status Published
Authors
Affiliation:
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
Perm State Medical University
Affiliation: Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
Affiliation: Perm State Pharmaceutical Academy
Affiliation: Perm State Medical University
Affiliation: Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences
Affiliation: Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences
Affiliation: Institute of Bioorganic Chemistry. M.M. Shemyakin and Yu.A. Ovchinnikov RAS
Journal nameRossiiskii immunologicheskii zhurnal
EditionVolume 12 Issue 3
Pages233-237
Abstract

The results of the study of the eff ect of MP-5 and MP-6 myelopeptides on the antibody response,  production of reactive oxygen species, IL-1β and IL-10 by peritoneal macrophages of mice against a back- ground of 6 hours of immobilization stress in vivo are presented. The stimulating eff ect of MP-5 and MP-6  on the production of reactive oxygen species and IL-1b by peritoneal macrophages was stimulated 6 hours after their administration. Myelopeptides also neutralized the inhibitory eff ect of immobilization stress on zymosan-induced production of reactive oxygen species by peritoneal macrophages and the antibody formation in the spleen.

Keywordsmyelopeptides, antibody formation, cytokines, stress, macrophages
Received22.11.2018
Publication date12.01.2019
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