Antipeptide activity of intestinal microsyмbyonts for the state of intestinal homeostasis estimation

 
PIIS102872210002385-8-1
DOI10.31857/S102872210002385-8
Publication type Article
Status Published
Authors
Affiliation: Institute for Cellular and Intracellular Symbiosis of Ural Branch of RAS
Affiliation: Orenburg State Medical University
Affiliation:
Institute for Cellular and Intracellular Symbiosis of Ural Branch of RAS
Orenburg State Medical University
Affiliation: Institute for Cellular and Intracellular Symbiosis of Ural Branch of RAS
Affiliation: Institute for Cellular and Intracellular Symbiosis of Ural Branch of RAS
Affiliation: Institute for Cellular and Intracellular Symbiosis of Ural Branch of RAS
Affiliation: Institute for Cellular and Intracellular Symbiosis of Ural Branch of RAS
Journal nameRossiiskii immunologicheskii zhurnal
EditionVolume 12 Issue 3
Pages222-226
Abstract

The paper presents the results of antipeptide activity against pro (TNFα, IFN-γ, IL-6, IL-17) and anti-infl ammatory (IL-10) cytokines of exometabolites of the intestinal microfl ora, isolated in patients with eubiosis, dysbiosis of the large intestine and reactive arthritis. Diff erences in strains of normofl ora and opportunistic microorganisms isolated from various sources, the spectrum of cytokines and the level of their decrease their content in the culture medium were determined upon co-cultivation with exometabolites of the cultures of microorganisms under study. The results obtained can be used to assess the immunoregulatory properties of microfl ora in various microecological conditions of the human colon and in extraintestinal infl ammatory pathology.

Keywordsintestinal microsymbionts, cytokines, dysbiosis, reactive arthritis
Received22.11.2018
Publication date12.01.2019
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