Does the apoptosis of lymphocytes affects on the immune status of the persons in the remote terms after chronic radiation exposure?

Affiliation:
Urals Research Center for Radiation Medicine of the FMBA of Russia
Southern-Urals State Medical University of the RF Ministry of Public Health

E. Blinova

Affiliation:
Urals Research Center for Radiation Medicine of the FMBA of Russia
Chelyabinsk State University

I. Dolgushin

Affiliation: Southern-Urals State Medical University of the RF Ministry of Public Health

Journal name

Rossiiskii immunologicheskii zhurnal

Edition

Volume 12 Issue 3

Pages

205-210

Abstract

In the remote period after chronic radiation exposure with predominant exposure to red bone marrow (average dose – 1.04±0.17 Gy, individual dose values: 0.01–2.96 Gy) in individuals with an increased frequency of apoptosis of peripheral blood lymphocytes there was no decrease in the number of T-lymphocytes and their main subpopulations, as well as B-lymphocytes and cells of innate immunity in the blood. The average values of the majority of indicators characterizing the innate immunity and serum cytokine levels in them corresponded to those in irradiated people with normal levels of peripheral blood lymphocytes apoptosis. In the exposed individuals with elevated levels of apoptosis of lymphocytes an increase in indicators of spontaneous NBT-test of neutrophils and reduced levels of serum IFNγ were observed. The results of the study showed that in the long term after chronic radiation exposure induction of peripheral blood lymphocyte apoptosis did not lead to the secondary immunodefi ciency development.

Keywords

chronic radiation exposure, lymphocyte, apoptosis, immune status

Received

22.11.2018

Publication date

12.01.2019

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GOST	Akleyev A., Blinova E., Dolgushin I. Does the apoptosis of lymphocytes affects on the immune status of the persons in the remote terms after chronic radiation exposure? // Rossiiskii immunologicheskii zhurnal – 2018. – V. 12. – Issue 3 C. 205-210 [Electronic resource]. URL: http://ras.jes.su/ruimm/s207987840001577-3-1-en (circulation date: 11.02.2025). DOI: 10.31857/S102872210002382-5
MLA	Akleyev, A., Blinova, E., Dolgushin, I. "Does the apoptosis of lymphocytes affects on the immune status of the persons in the remote terms after chronic radiation exposure?." Rossiiskii immunologicheskii zhurnal 12.3 (2018):205-210. DOI: 10.31857/S102872210002382-5
APA	Akleyev A., Blinova E., Dolgushin I. (2018). Does the apoptosis of lymphocytes affects on the immune status of the persons in the remote terms after chronic radiation exposure?. Rossiiskii immunologicheskii zhurnal 12(3), pp.205-210 DOI: 10.31857/S102872210002382-5

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