Does the apoptosis of lymphocytes affects on the immune status of the persons in the remote terms after chronic radiation exposure?

 
PIIS102872210002382-5-1
DOI10.31857/S102872210002382-5
Publication type Article
Status Published
Authors
Affiliation:
Urals Research Center for Radiation Medicine of the FMBA of Russia
Southern-Urals State Medical University of the RF Ministry of Public Health
Affiliation:
Urals Research Center for Radiation Medicine of the FMBA of Russia
Chelyabinsk State University
Affiliation: Southern-Urals State Medical University of the RF Ministry of Public Health
Journal nameRossiiskii immunologicheskii zhurnal
EditionVolume 12 Issue 3
Pages205-210
Abstract

In the remote period after chronic radiation exposure with predominant exposure to red bone marrow (average dose – 1.04±0.17 Gy, individual dose values: 0.01–2.96 Gy) in individuals with an increased frequency of apoptosis of peripheral blood lymphocytes there was no decrease in the number of T-lymphocytes and their main subpopulations, as well as B-lymphocytes and cells of innate immunity in the blood. The average values of the majority of indicators characterizing the innate immunity and serum cytokine levels in them corresponded to those in irradiated people with normal levels of peripheral blood lymphocytes apoptosis. In the exposed individuals with elevated levels of apoptosis of lymphocytes an increase in indicators of spontaneous NBT-test of neutrophils and reduced levels of serum IFNγ were observed. The results of the study showed that in the long term after chronic radiation exposure induction of peripheral blood lymphocyte apoptosis did not lead to the secondary immunodefi ciency development.

Keywordschronic radiation exposure, lymphocyte, apoptosis, immune status
Received22.11.2018
Publication date12.01.2019
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