Influence of macrophage modulation on the state of extra islet insulin-producing system in hypergycemia

Affiliation:
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences
Ural Federal University named after the first President of Russia B.N. Yeltsin

A. Belousova

Affiliation: Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences

I. Gette

Affiliation:
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences
Ural Federal University named after the first President of Russia B.N. Yeltsin

I. Danilova

Affiliation:
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences
Ural Federal University named after the first President of Russia B.N. Yeltsin

M. Abidov

Affiliation: Ural Federal University named after the first President of Russia B.N. Yeltsin

Journal name

Rossiiskii immunologicheskii zhurnal

Edition

Volume 12 Issue 3

Pages

439-443

Abstract

Restoring of insulin-synthesizing cell pool by means of macrophage activity modulation can be a promising direction in the treatment of diabetes mellitus. Modeling of type 2 diabetes mellitus in rats (110 mg / kg of nicotinamide and 65 mg / kg of streptozotocin) caused a spontaneous compensatory increase in the number of extra islet insulin-producing cells up to 30 days, followed by a decrease in the number of these cells by 60 days without enhancing their functional activity. Modulation of macrophage activity with the administration of aminophthalhydrazide (2 mg / kg, 20 injections) to diabetic rats was accompanied by an increase in the number of the extra islet insulin-producing cells, the accumulation of insulin in all the studied groups of these cells, and a reduction in hyperglycemia.

Keywords

macrophages, streptozotocin diabetes, extra islet insulin-producing cells

Acknowledgment

The work was performed in the framework of the state. tasks IIII UB RAS. No. of state. registration of the topic AAAA-A18–118020590107–0.

Received

12.01.2019

Publication date

12.01.2019

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GOST	Sokolova K., Belousova A., Gette I., Danilova I., Abidov M. Influence of macrophage modulation on the state of extra islet insulin-producing system in hypergycemia // Rossiiskii immunologicheskii zhurnal – 2018. – V. 12. – Issue 3 C. 439-443 [Electronic resource]. URL: http://ras.jes.su/ruimm/s102872210002424-1-1-en (circulation date: 24.04.2024). DOI: 10.31857/S102872210002424-1
MLA	Sokolova, K., Belousova, A., Gette, I., Danilova, I., Abidov, M. "Influence of macrophage modulation on the state of extra islet insulin-producing system in hypergycemia." Rossiiskii immunologicheskii zhurnal 12.3 (2018):439-443. DOI: 10.31857/S102872210002424-1
APA	Sokolova K., Belousova A., Gette I., Danilova I., Abidov M. (2018). Influence of macrophage modulation on the state of extra islet insulin-producing system in hypergycemia. Rossiiskii immunologicheskii zhurnal 12(3), pp.439-443 DOI: 10.31857/S102872210002424-1

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