Development of experimental sample of a new hepatoprotector

Affiliation: Federal State Budgetary Scientific Institution Research Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences

Journal name

Rossiiskii immunologicheskii zhurnal

Edition

Volume 12 Issue 3

Pages

301-305

Abstract

The present research is devoted to the design of combined hepatoprotector using culture strain Bacillus subtilis B-9906 and isolated from the same strain of the metabolic complex. A series of experiments with the use of explanted rat hepatocytes in the modeling of toxic carbon tetrachloride in direct experiments has demonstrated the presence of hepatoprotective action directly in the metabolic complex. The increase in proliferative activity of hepatocyte cell culture was observed after 48 hours, the culture was fully restored after 96 hours.

Keywords

probiotic microorganisms, biologically active substances, metabolites, design, hepatoprotective effect

Acknowledgment

The work was performed as part of the state assignment of the IIB UB RAS (R & D Number No. AAAA-A18–118020690020–1).

Received

11.01.2019

Publication date

12.01.2019

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GOST	Zabokritsky N. Development of experimental sample of a new hepatoprotector // Rossiiskii immunologicheskii zhurnal – 2018. – V. 12. – Issue 3 C. 301-305 [Electronic resource]. URL: http://ras.jes.su/ruimm/s102872210002399-3-1-en (circulation date: 26.04.2024). DOI: 10.31857/S102872210002399-3
MLA	Zabokritsky, N. "Development of experimental sample of a new hepatoprotector." Rossiiskii immunologicheskii zhurnal 12.3 (2018):301-305. DOI: 10.31857/S102872210002399-3
APA	Zabokritsky N. (2018). Development of experimental sample of a new hepatoprotector. Rossiiskii immunologicheskii zhurnal 12(3), pp.301-305 DOI: 10.31857/S102872210002399-3

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1. Zabokritskij N. A. Ehksperimental'naya otsenka korrektsii gumoral'nogo immuniteta gepatoprotektornym preparatom gepatobiol u laboratornykh zhivotnykh s ostrym toksicheskim gepatitom. Rossijskij immunologicheskij zhurnal, 2017, 11, 2 (20), 123–126. [Zabokritskiy N. A. Experimental estimation of correction of humoral immunity hepatoprotective drug hepatobiol in laboratory animals C acute toxic hepatitis, 2017, 11, 2 (20), 123–126].

2. Zabokritskij N. A. Obosnovanie napravlenij v razrabotke i ehksperimental'nom izuchenii novykh farmakologicheskikh preparatov na osnove probiotikov i ikh biologicheski aktivnykh produktov: avtoref. dis. … d-ra. med. nauk., 2014. 3–16. [Zabokritskiy N. A. Study areas in the development and experimental study of new pharmacological products based on probiotics and their bioactive products: abstract of dis. … dr. med. sciences, 2014. 3–16].

3. Holzapfel W. H., Schillinger U. Introduction to preand probiotics. Food Research International 35, 2002, 109–116.

4. Kailasapathy K. A., Chin J. Survival and therapeutic potential of probiotic organisms with reference to Lactobacillus acidophilus and Bifi dobacterium spp. Immunol. Cell. Biol., 2000, 78, 80–88.

5. Lee Y. K., Salminen S. Handbook of Probiotics and Prebiotics. John Wiley and Sons, Ltd., 2009, 132–144.

6. Russel J., Cohn R. Probiotics. U.K., Edinburgh: LENNEX Corp. 2012, 5–58.

7. Labinskaya A. S. Mikrobiologiya s tekhnikoj mikrobiologicheskikh issledovanij. Binom, M., 2012. 72–124. [Labinskaya A. S. Microbiology with technique of microbiological studies.: Binom, Moscow, 2012, 16–51].