Immune biomarkers of in-stent restenosis after percutaneous coronary interventions in myocardial infarction and stable angina patients

The study was aimed to assess the prognostic role of infl ammation biomarkers to evaluate the risk for restenosis in myocardial infarction and stable angina patients undergoing percutaneous coronary intervention. The blood samples were tested immediately before and 7 days after percutaneous coronary intervention for IFN-γ, IL-6, IL-8, IL-17, TNF-α, TNF-β, TGF-β1 and TGF-β2. The key predictors of restenosis after percutaneous coronary intervention during one year were abnormal rates of IFN-γ pre-PCI (OR=5,21) and 7 days after (OR=3,84), IL-6 pre-PCI (OR=1,59), IL-8 pre-PCI (OR=1,73), IL-17 pre- PCI (OR=3,07) and 7 days after (OR=2,34), TNF-α pre-PCI (OR=1,88), TNF-β pre-PCI (OR=1,98) and growth factors: TGF-β1 7 days after PCI (OR=1,82) and TGF-β2 7 days after PCI (OR=2,04).

Keywords

cytokines, percutaneus coronary intervention, myocardial infarction, stable angina, restenosis

Received

23.11.2018

Publication date

12.01.2019

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GOST	Grachev N., Semenikhin A., Turmova E., Rublev V., Nazarenko S., Anohina N. Immune biomarkers of in-stent restenosis after percutaneous coronary interventions in myocardial infarction and stable angina patients // Rossiiskii immunologicheskii zhurnal – 2018. – V. 12. – Issue 3 C. 255-260 [Electronic resource]. URL: http://ras.jes.su/ruimm/s102872210002391-5-1 (circulation date: 23.03.2025). DOI: 10.31857/S102872210002391-5
MLA	Grachev, N., Semenikhin, A., Turmova, E., Rublev, V., Nazarenko, S., Anohina, N. "Immune biomarkers of in-stent restenosis after percutaneous coronary interventions in myocardial infarction and stable angina patients." Rossiiskii immunologicheskii zhurnal 12.3 (2018):255-260. DOI: 10.31857/S102872210002391-5
APA	Grachev N., Semenikhin A., Turmova E., Rublev V., Nazarenko S., Anohina N. (2018). Immune biomarkers of in-stent restenosis after percutaneous coronary interventions in myocardial infarction and stable angina patients. Rossiiskii immunologicheskii zhurnal 12(3), pp.255-260 DOI: 10.31857/S102872210002391-5

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