About Us and Our Oncolytic Bacteria

 
PIIS0032874X0000478-4-1
DOI10.31857/S0032874X0000478-4
Publication type Article
Status Published
Authors
Affiliation: Institute of Experimental Medicine. St.Petersburg State University
Address: Russian Federation
Journal namePriroda
EditionIssue №8
Pages3-9
Abstract

It is known that almost all human diseases, including cancer, occur with changes in microbiome. However, the role of microorganisms, in particular, bacteria, in the development of cancer is still incomprehensible. It was shown that infections caused by different pathogens may in some cases lead to the disappearance of tumor development. The greatest amount of data has been accumulated on the use of Group A streptococci as antitumor bacteria. Herewith, modification of streptococci by genetic engineering could improve the anti-cancer features. Author of the article hypothesize that the opportunistic bacteria might have a biological role of eliminating the cancer cells from the organism.

Keywordscancer, oncolytic bacteria, Streptococcus pyogenes.
Received29.09.2018
Publication date04.10.2018
Number of characters697
Cite   Download pdf To download PDF you should sign in
Размещенный ниже текст является ознакомительной версией и может не соответствовать печатной

views: 1731

Readers community rating: votes 0

1. Tjalsma H., Boleij A., Marchesi J.R., Dutilh B.E. A bacterial driver-passenger model for colorectal cancer: beyond the usual suspects. Nat Rev Microbiol. 2012; 10(8): 575–582. Doi:10.1038/nrmicro2819.

2. Ferlay J., Soerjomataram I., Dikshit R. et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int. J. Cancer. 2015; 136(5): E359–E386. Doi:10.1002/ijc.29210.

3. Nair N., Kasai T., Seno M. Bacteria: prospective savior in battle against cancer. Anticancer Res. 2014; 34(11): 6289–6296.

4. Karpisski T.M. Anticancer activity of bacterial proteins and peptides. Pharmaceutics. 2018; 10(2): E54. Doi:10.3390/pharmaceutics10020054.

5. Fiedler T., Straussab M., Hering S. et al. Arginine deprivation by arginine deiminase of Streptococcus pyogenes controls primary glioblastoma growth in vitro and in vivo. Cancer Biol. Ther. 2015; 16(7): 1047–1055. Doi:10.1080/15384047.2015.1026478.

6. Maletzki C., Rosche Y., Riess C. et al. Deciphering molecular mechanisms of arginine deiminase-based therapy — Comparative response analysis in paired human primary and recurrent glioblastomas. Chem. Biol. Interact. 2017; 278: 179–188. Doi:10.1016/j.cbi.2017.10.007.

7. Krzykawski M.P. Combined bacterial and viral treatment: a novel anticancer strategy. Cent Eur J Immunol. 2015; 40(3): 366–372. Doi:10.5114/ceji.2015.54601.

8. Maletzki C., Klier U., Obst W. et al. Reevaluating the concept of treating experimental tumors with a mixed bacterial vaccine: Coley’s Toxin. Clin. Dev. Immunol. 2012; 2012: 230625. Doi:10.1155/2012/230625.

9. Old L.J., Clark D.A., Benacerraf B. Effect of Bacillus Calmette-Guerin infection on transplanted tumors in the mouse. Nature. 1959; 184: 291–292. Doi:10.1038/184291a0.

10. Morales A., Eidinger D., Bruce A.W. Intracavitary Bacillus Calmette Guerin in the treatment of superficial bladder tumors. J. Urol. 1976; 116(2): 180–183. Doi:10.1016/S0022-5347(17)58737-6.

11. Bonavida B., Katz J., Hoshino T. Mechanism of NK activation by OK 432 (Streptococcus pyogenes). I. Spontaneous release of NKCF and augmentation of NKCF production following stimulation with NK target cells. Cell Immunol. 1986; 102(1): 126–135. Doi:10.1016/0008-8749(86)90331-X.

12. Suvorova M. A., Kramskaya T. A., Suvorov A.N., Kiseleva E.P. Inactivation of M111 protein gene modifies Streptococcus pyogenes interactions with mouse macrophages in vitro. Bull. Exp. Biol. Med. 2018; 164(3): 347–350. Doi:10.1007/s10517-018-3987-z.

13. Suvorova M. A., Kramskaya T. A., Duplik N.V. i dr. Vliyanie inaktivatsii gena M-belka na protivoopukholevye svojstva zhivykh Streptococcus pyogenes v ehksperimente. Voprosy onkologii. 2017; 63(5): 803–807. [Suvorova M. A., Kramskaya T. A., Duplik N.V. et al. Influence of inactivation of the M protein gene on antitumor activity of live Streptococcus pyogenes in experiment. Problems in oncology. 2017; 63(5): 803–807. (In Russ.).]

14. McMillan D.J., Drize P. A., Vu T. et al. Updated model of group A Streptococcus M proteins based on a comprehensive worldwide study. Clin. Microbiol. Infect. 2013; 19(5): E222–E229. Doi:10.1111/1469-0691.12134.

Система Orphus

Loading...
Up