China is one of the world largest manufacturer, exporter, foreign investor and the world's second largest consumer market after the United States. Recently the country economy faces both internal and external challenges, transformations of the world economy and the US-China trade wars. At the beginning of 2020, the target year to finish the building of an all-round moderately prosperous society (xiao kang), the final year for the fight against poverty and the end of the 13th Five-Year Plan period (2016–2020), China was the first country to be hit by the coronavirus outbreak which spread across the globe then. The pandemic has serious economic and social impacts, especially for China. This article analyses and estimates the effects of the new disease on its largest regional economy of Guangdong province this year.