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Early Deсline in Rat Soleus Passive Tension with Hindlimb Unloading: Inactivation of Cross-bridges or Activation of Calpains?
 
PIIS086956520001751-9-1
DOI10.31857/S086956520001390-2
Publication type Article
Status Published
Authors
Irina Petrova 
Affiliation: Institute of Biomedical Problems, RAS
Address: Russian Federation, Moscow
B. Shenkman
Affiliation: Institute of Biomedical Problems, RAS
Address: Russian Federation, Moscow
I. Kozlovskaya
Affiliation: Institute of Biomedical Problems, RAS
Address: Russian Federation, Moscow
A. Tsaturyan
Affiliation: Institute of Mechanics, M.V. Lomonosov Moscow University
Address: Russian Federation
T. Mirzoev
Affiliation: Institute of Biomedical Problems, RAS
Address: Russian Federation, Moscow
S. Tyganov
Affiliation: Institute of Biomedical Problems, RAS
Address: Russian Federation, Moscow
Journal nameDoklady Akademii nauk
Edition
Pages333-335
Abstract

The study was aimed at testing the hypotheses about the role of the cross- bridges and calpains in reduction of rat soleus passive tension under conditions of hindlimb unloading. To this end, we used an inhibitor of μ-calpain PD 150606 as well as a blocker of acto-myosin interaction (blebbistatin). It was found for the first time that a decrease in passive tension of rat soleus after 3-day hindlimb unloading is associated with the activity of μ-calpain, and does not depend on the processes of cross-bridges formation.

Keywords
Received16.10.2018
Publication date13.11.2018
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