Influence of Alpha-Fetoprotein on the Naive T-Helpers Conversion to Effector Subpopulations of Memory T-Cells

 
PIIS086956520003083-4-1
DOI10.31857/S086956520003083-4
Publication type Article
Status Published
Authors
Occupation: Senior Research Fellow
Affiliation:
Institute of Ecology and Genetics of Microorganisms, Ural branch of RAS
Perm State University
Address: Russian Federation, Perm
Occupation: Junior Research Fellow
Affiliation: Institute of Ecology and Genetics of Microorganisms, Ural branch of RAS
Address: Russian Federation, Perm
Affiliation: Institute of Ecology and Genetics of Microorganisms of the Ural Branch of the Russian Academy of Sciences
Address: Russian Federation, Perm
Affiliation:
Institute of Ecology and Genetics of Microorganisms of the Ural Branch of the Russian Academy of Sciences
Perm State University
Address: Russian Federation, Perm
Affiliation: Perm State University
Address: Russian Federation, Perm
Affiliation:
Institute of Ecology and Genetics of Microorganisms, Ural branch of RAS
Perm State University
Ural Federal University
Address: Russian Federation, Perm
Affiliation:
Institute of Ecology and Genetics of Microorganisms, Ural branch of RAS
Perm State University
Ural Federal University
Address: Russian Federation, Perm
Journal nameDoklady Akademii nauk
EditionVolume 482 Issue 4
Pages467-470
Abstract

The effect of native alpha-fetoprotein (AFP) on the conversion of naive T-helpers to central memory T-cells (TCM) and effector subpopulations of the preterm differentiated (TEM) and terminal-differentiated (TEMRA) memory T cells was studied. It was found that AFP prevented the conversion of naive T-helpers into effector subpopulations of memory T cells (TEM and TEMRA) while reducing the total production of IL-4 and IFN-γ by the populations under study. The obtained data reveal a new role of AFP in the formation of immune tolerance during pregnancy.

Keywordsalpha-fetoprotein (AFP), immune tolerance, T-cells memory, pregnancy
AcknowledgmentThe research was supported by the RFBR grant № 16-44-590971, and the UrFU competitiveness enhancement program, Resolution № 211 of the Government of the Russian Federation, Contract № 02.A03.21.0006
Received10.11.2018
Publication date10.11.2018
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