In last years, the position of Africa and Asia in the global illicit consumption of different types of drugs escalated. The paper considers the geographical features of the markets of illegal plant-based drug use (on the example of cannabis, cocaine and several opiates) in Asia and Africa at various scale levels. The author analyzed the geography of the main supply routes as well as places of drug seizures. It was found that in many regions of the continents there is a well-developed network of drug supply channels characterized by interregional and intraregional types of links. The type depends on either characteristics of drug substance or geographical position of drug hubs on drug routes. A territorial concentration of drug seizures on interregional and interstate levels is inherent for the continents. Main Asian and African drug-transit areas in the global illicit drug-trafficking system are characterized by intermodality of transit i.e. drug dealers can smuggle through such territories several types of illegal drugs substances. At present, there is a tendency of drug users’ increase not only in the whole world but especially on the both continents: beginning with XXI century Africa and Asia demonstrate the highest growth rate of individuals with narcotic abuse in comparison with the rest global drug markets (Americas, Europe and Oceania). The assessment of the value of the drug markets made it possible to determine the degree of its impact on the economies of Asian and African states. The negative influence of legalized drug-incomes on the economy will be exclusively negative.