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A Failure that Paved the Road to Success: Induced Freemartins and Discovery of Feedback Control in the Endocrine System by Carl R. Moore and Dorothy Price
 
PIIS020596060020595-6-1
DOI10.31857/S020596060020595-6
Publication type Article
Status Published
Authors
Oleg Belozerov 
Affiliation: S. I. Vavilov Institute for the History of Science and Technology, Russian Academy of Sciences
Address: Moscow, Ul. Baltiyskaya, 14
Journal nameVoprosy istorii estestvoznaniia i tekhniki
EditionVolume 43 Issue 2
Pages263-272
Abstract

In the second half of the 1910s, on Frank R. Lillie’s suggestion, his pupil Carl Moore attempted to create freemartins, females born as a twin to a normal male that are sterile as a result of exposure to masculinizing hormones produced by the male twin, in the laboratory; not long before then, the mechanism of freemartinism was elucidated by J. Tandler and K. Keller and by F. R. Lillie. Although Moore’s attempt failed, Moore and Dorothy Price, who joined him in 1922, thus became involved in a series of studies that culminated in the discovery of feedback between the gonads and pituitary in mammals on the cusp of the 1920s and 1930s. The article analyzes the history of this discovery and some conclusions its authors had derived from it.

KeywordsF. R. Lillie, C. R. Moore, D. Price, freemartins, antagonism of gonads, feedback, gonads, pituitary
Received27.06.2022
Publication date27.06.2022
Number of characters20181
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