The article is devoted to the development of the political process in the Indo-Pacific region – a very important world area. Here interests of word leaders the USA and China and other leading regional powers (Russia, Japan and India) collide. Washington negatively perceives the actions of China, which stands for the establishment of a new multipolar world order and does not intend to put up with the hegemony of the United States. The main issue that irritates the American leadership is the consistent formation by Beijing of structures alternative to the global institutions created after the Second World War. On the American side, attempts are being made to isolate this "revisionist power" from the world community. An important task of China's foreign policy is to strengthen multipolarity in international relations, directed against American hegemony. China is making vigorous efforts to neutralize the attempts of the United States and its allies to contain PRC, to assert its status as a super-power. China's claims to regional leadership are met with persistent opposition from the United States, which seeks to increase tension near the Chinese borders, increasing it around Taiwan, expanding and strengthening the Eastern segment of the U.S. missile defense in South Korea and Japan. The approaches and policies of the most influential states in the Indo–Pacific region are considered in the context of recent events, intertwining and contrasting their interests and the possibility of emergence of international conflicts in this region. Contradictions between the leading States of East Asia are manifested against the background of uncertainty and unpredictability of the USA and China's policies. The article notes that the confrontation between the United States and the People's Republic of China leads to the formation of the countries guided by them, which in fact divides the leading countries of the region into two opposing groups and increases regional tension. Rivalry between superpowers is carried out in the atmosphere of mistrust and suspiciousness, growth of nationalism, urges on a race of arms.