Spermatogenesis and mast cells of the testes with damage and against the background of the introduction of glucocorticosteroids

 
PIIS102872210002431-9-1
DOI10.31857/S102872210002431-9
Publication type Article
Status Published
Authors
Affiliation:
Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences
Ural Federal University named after the first President of Russia B.N. Yeltsin
Affiliation: Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences
Affiliation:
Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences
Ural Federal University named after the first President of Russia B.N. Yeltsin
Affiliation: Ural Federal University named after the first President of Russia B.N. Yeltsin
Journal nameRossiiskii immunologicheskii zhurnal
EditionVolume 12 Issue 3
Pages479-485
Abstract

The immune system plays an important role in the regulation of restorative processes in various tissues and organs, including immunoprivileged ones, which include the testes. Mast cells (TK) are one of the elements of the microenvironment of the testis and take part in maintaining testicular homeostasis. With various traumas of testes, therapy with corticosteroids with anti-infl ammatory and immunosuppressive properties is indicated. The role of TC in the process of recovery of spermatogenesis with the administration of corticosteroids remains unknown, which was the purpose of this study. It was found that after damage to the hemato-testicular barrier of rats, against the background of the introduction of prednisolone, there is an increase in the synthetic activity of TC, with an invariable in the number and the level of degranulation. This phenomenon is refl ected positively on the process of recovery of spermatogenesis, the development of destructive processes is weakened, as there is a tendency to increase the number of spermatogonia and decrease the number of nonfunctioning tubules.

Keywordsspermatogenesis, mast cells, testes, corticosteroids
AcknowledgmentThe work was performed as part of the state assignment of IIF UB RAS (subject number AAAA-A18–118020590108–7).
Received12.01.2019
Publication date12.01.2019
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