The role of TCR-activation in the formation of small subpopulations of T helpers

 
PIIS102872210002426-3-1
DOI10.31857/S102872210002426-3
Publication type Article
Status Published
Authors
Affiliation: Institute of Ecology and Genetics of Microorganisms UB RAS
Affiliation: Institute of Ecology and Genetics of Microorganisms UB RAS
Affiliation: Institute of Ecology and Genetics of Microorganisms UB RAS
Affiliation: Institute of Ecology and Genetics of Microorganisms UB RAS
Affiliation: Institute of Ecology and Genetics of Microorganisms UB RAS
Journal nameRossiiskii immunologicheskii zhurnal
EditionVolume 12 Issue 3
Pages449-453
Abstract

The role of the independent eff ect of TCR-activation in the formation of small subpopulations of T-helpers (Treg, TCM, TEM, TEMRA) was studied. It was shown that under the conditions of TCR activation, cells were redistributed in favor of eff ector subpopulations (TEM, TEMRA), while the number of naive T cells and TCM decreased. What about Treg, it was demonstrated that TCR-activation of cells resulted in increased intracellular expression of FOXP3, HELIOS and CTLA-4. In general, the presence of the TCR-activator leads to an increase in the number of eff ector T-helpers, which is accompanied by a simultaneous increase in the level of suppressive Treg.

KeywordsTCR, T-helpers, Treg, memory T cells, naive T cells, T cells of central memory
AcknowledgmentThe work was performed within the framework of the state assignment, state registration N: 01201353248.
Received12.01.2019
Publication date12.01.2019
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