The role of TCR-activation in the formation of small subpopulations of T helpers

The role of the independent eff ect of TCR-activation in the formation of small subpopulations of T-helpers (Treg, TCM, TEM, TEMRA) was studied. It was shown that under the conditions of TCR activation, cells were redistributed in favor of eff ector subpopulations (TEM, TEMRA), while the number of naive T cells and TCM decreased. What about Treg, it was demonstrated that TCR-activation of cells resulted in increased intracellular expression of FOXP3, HELIOS and CTLA-4. In general, the presence of the TCR-activator leads to an increase in the number of eff ector T-helpers, which is accompanied by a simultaneous increase in the level of suppressive Treg.

Keywords

TCR, T-helpers, Treg, memory T cells, naive T cells, T cells of central memory

Acknowledgment

The work was performed within the framework of the state assignment, state registration N: 01201353248.

Received

12.01.2019

Publication date

12.01.2019

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GOST	Timganova V., Zamorina S., Bochkova M., Khramtsov P., Raev M. The role of TCR-activation in the formation of small subpopulations of T helpers // Rossiiskii immunologicheskii zhurnal – 2018. – V. 12. – Issue 3 C. 449-453 [Electronic resource]. URL: http://ras.jes.su/ruimm/s207987840001620-1-1-en (circulation date: 25.04.2024). DOI: 10.31857/S102872210002426-3
MLA	Timganova, Valeriya, Zamorina, Svetlana, Bochkova, Maria, Khramtsov, Pavel, Raev, M. "The role of TCR-activation in the formation of small subpopulations of T helpers." Rossiiskii immunologicheskii zhurnal 12.3 (2018):449-453. DOI: 10.31857/S102872210002426-3
APA	Timganova V., Zamorina S., Bochkova M., Khramtsov P., Raev M. (2018). The role of TCR-activation in the formation of small subpopulations of T helpers. Rossiiskii immunologicheskii zhurnal 12(3), pp.449-453 DOI: 10.31857/S102872210002426-3

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