Modulation of functional activity of mast cells by cholinergic agents

Publication type Article
Status Published
Affiliation: Institute of Experimental Medicine
1Institute of Experimental Medicine
The I.P. Pavlov First St. Petersburg State Medical University
Journal nameRossiiskii immunologicheskii zhurnal
EditionVolume 12 Issue 3

Being immunocompetent cells, mast cells at the same time have a number of properties characteristic of cells of the nervous system, which is why they are often viewed as key intermediaries between the integrating systems of the body. There is an increasing interest of the scientifi c community in the anti-infl ammatory activity of the parasympathetic nervous system. Despite this, the question of the mechanisms of cholinergic regulation of mast cells has not been studied suffi ciently. As a model of mast cells, we used the HMC-1 human mast line cells. The results of our study showed that carbachol (Cch), a functional analog of acetylcholine, simultaneously exhibits properties of the histamine liberator and the suppressor of IgG-induced activation of mast cells. This dual eff ect of the neurotransmitter may indicate the presence of a cholinergic tone supporting the excitation of mast cells at a certain level. The modulating eff ect of Cch on the functional activity of HMC-1 cells is realized through nicotinic acetylcholine receptors (n-AChR). The data obtained contribute to deepening the concept of the mechanisms of negative regulation of mast cells.

Keywordshuman mast cells, acetylcholine, cholinomimetics, cholinolytics, bungarotoxin
Publication date12.01.2019
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