The role of human chorionic gonadotropin and its peptide fragments in the regulation of IDO expression by human monocytes

 
PIIS102872210002400-5-1
DOI10.31857/S102872210002400-5
Publication type Article
Status Published
Authors
Affiliation: Institute of Ecology and Genetics of Microorganisms UB RAS
Affiliation: Institute of Ecology and Genetics of Microorganisms UB RAS
Affiliation: Institute of Ecology and Genetics of Microorganisms UB RAS
Affiliation: Institute of Ecology and Genetics of Microorganisms UB RAS
Affiliation: Institute of Ecology and Genetics of Microorganisms UB RAS
Journal nameRossiiskii immunologicheskii zhurnal
EditionVolume 12 Issue 3
Pages306-310
Abstract

The role of human chorionic gonadotropin (hCG) and its peptide fragments of β-subunit (LQGV, AQGV, VLPALP) in the regulation of indolеamine-2,3-dioxygenase (IDO) expression in human monocytes was studied in vitro. It is elucidated, that a high concentration of hCG (20 μg/ml) had an independent stimulatory eff ect on the expression of IDO in LPS -, and the IFN-γ – induced monocytes. Peptides AQGVand LQGV (20 μg/ml) also stimulated LPS-induced expression of IDO, but had no eff ect on IFN- γ-induced expression of the enzyme. At the same time, peptide VLPALP (20 μg/ml) provided the stimulatory eff ect only on the IFN-γ-induced expression of IDO. Simultaneously, peptides AQGV and VLPALP increased the production of IL-1β monocytes under LPS-stimulation, while hCG did not exert any independent eff ect. Generally, hCG and oligopeptides of β-hCG subunit enhance the expression of IDO by monocytes, which eventually contributes to peripheral immune tolerance development.

Keywordschorionic gonadotropin, regulatory peptides (LQGV, AQGV, VLPALP), indoleamine-2,3- dioxygenase (IDO), immune tolerance, monocytes
AcknowledgmentThe work was performed in the framework of the state assignment, N state registration topics: 01201353248
Received11.01.2019
Publication date12.01.2019
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