Comparative analysis of mettaloproteinase system and their tissue inhibitors at periodontitis in patients with diabetes mellitus type II

 
PIIS102872210002390-4-1
DOI10.31857/S102872210002390-4
Publication type Article
Status Published
Authors
Affiliation: Pacific State Medical University
Affiliation: Pacific State Medical University
Affiliation: Pacific State Medical University
Affiliation: Pacific State Medical University
Affiliation: Pacific State Medical University
Journal nameRossiiskii immunologicheskii zhurnal
EditionVolume 12 Issue 3
Pages247-254
Abstract

The article presents the results of a comparative study of the systemic and local levels of matrix metalloproteinases MMP-2, MMP-8, MMP-9 and their tissue inhibitors TIMP-1, TIMP-2 in patients with periodontitis and type II diabetes (group I) and periodontitis without diabetes mellitus (group II). 65 patients were examined, including: 30 patients. – I group and 35 people. – II group. The control group consisted of healthy volunteers (30 people). In both patients, a signifi cant increase in MMP-9, TIMP-1, -2 in the serum, an increase in MMP-2, -8, -9, TIMP-1, -2 in saliva, as well as MMP-8 and MMP-9 in the blood obtained from the microcirculatory bed of the gingival patients. A decrease in MMP-2 and MMP-8 levels in the blood serum, as well as a decrease in the levels of MMP-2 and TIMP-2 in the blood, obtained from the ICR of the gingiva in patients of groups 1 and 2, was determined. In patients with periodontitis against diabetes mellitus II, hyperproduction of MMP-9 was established, as well as an increase in the levels of TIMP-1 in blood obtained from the ICR of the gum. In the group of patients without concomitant pathology, on the contrary, there was a more pronounced increase in MMP-8 levels, as well as an increase in TIMP-1 in saliva and TIMP-2 in serum.

Keywordsperiodontitis, diabetes mellitus, ММР-2, ММР-8, ММР-9, TIMP-1, TIMP-2
Received11.01.2019
Publication date12.01.2019
Cite   Download pdf To download PDF you should sign in
Размещенный ниже текст является ознакомительной версией и может не соответствовать печатной

views: 1215

Readers community rating: votes 0

1. Biktimerova O. O., Redinova T. L., Zorin A. Yu. Changes in clinical and immunological parameters of the oral cavity in patients with chronic generalized periodontitis in the treatment of probiotics. Pacifi c Medical Journal 2014, 3, 34–36

2. Borzikova N. S. Markers of infl ammatory processes in periodontal diseases. Medical Council 2015, 2, 78–79

3. Bulkina N. V., Vedyaeva A. P., Savina E. A. Comorbidity of periodontal diseases and somatic pathology. The medical bulletin of the North Caucasus 2012, 3, 110–115

4. Grinin V. M., Bayar U., Karaoglanova Т. B. Matrix metalloproteinases in periodontitis. Dentistry 2011, 6, 80–84

5. Zorin O. A., Kulakov A. A., Boriskina O. A. Interrelation of polymorphism of MMP2 and MMP9 genes with the development of periodontal diseases. Palliative medicine and rehabilitation 2011, 2, 49–52

6. Zorin O. A., Boriskina O. A., Leonovich O. A., Rebrikov D. V. Genetic factors predisposing to the development of aggressive periodontitis: matrix proteins, matrixins and their regulators. Dentistry 2013, 1, 76–83

7. Zyryanov B. N. Dental markers of the oral cavity in type 2 diabetes mellitus in middle-aged people. The young scientist is 2014, 3, 178–181

8. Karpuk I. Yu. The importance of matrix metalloproteinases-8 and-9 in the development of allergopathology of the oral mucosa caused by intolerance to denture prosthetic materials. Bulletin VSMU2015, 14, 2, 89–96

9. Markelova E. V., Iutskovskaya I. A. Local cytokine status in men with chronic chlamydial and ureaplasmic urethritis. Far Eastern Medical Journal 2007, 3, 83–86

10. Rogova L. N., Shesternina N. V., Zamecnik T. V., Fastova I. A. Matrix metalloproteinases, their role in physiological and pathological processes (review). Bulletin of new medical technologies 2011, XVIII, 2, 86–89

11. Solovy E. A., Karaoglanova T. B., Kushlinskiy N. E., Yanushevich O. O. Matrix metalloproteinases and infl ammatory cytokines in the oral fl uid of patients with chronic generalized periodontitis with various constructional materials of tooth and dentition restorations. Clinical laboratory diagnostics 2013, 10, 18–21

12. Amalinei C. Matrix metalloproteinases involvement in pathologic conditions. Romanian J. Morphology Embriology. 2010, 51, 215–228.

13. Figueredo C. M., Areas A., Miranda L. A., Fischer R. G., Gustafsson A. The short-term eff ectiveness of non-surgical treatment in reducing protease activity in gingival crevicular fl uid from chronic periodontitis patients. J Clin Periodontol. 2004, 31, 615–619.

14. Jotwani R., Eswaran S. V., Moonga S. et al. MMP-9/ TIMP-1 imbalance induced in human dendritic cells by Porphyromonas gingivalis. FEMS Immunol Med Microbiol. 2010, 58(3), 314–321.

15. Korostoff J. M., Wang J. F., Sarment D. P., Stewart J. C. Analysis of in situ protease activity in chronic adult periodontitis patients: expression of activated MMP-2 and 40 kDa serine protease. J. Periodontol. 2010, 71(3), 353–360.

16. Kushlinskii N. E., Solovykh E. A., Karaoglanova T. B., Boyar U. Matrix metalloproteinases and infl ammatory cytokines in oral fl uid of patients with chronic generalized periodontitis and various construction materials. Bull Exp Biol Med. 2012, 153, 72–76.

17. Maesco G., Bravo M., Bascones F. Levels of metalloproteinase- 2 and -9 and tissue inhibitor of matrix metal loproteinase- 1 in gingival crevicular fl uid of patients with periodontitis, gingivitis, and healthy gingival. Quintessence Int. 2007, 38, 247–252.

18. Makela M., Salo T., Uitto V. J., Larjava H. Matrix metalloproteinases (MMP-2 and MMP-9) of the oral cavity: cellular origin and relationship to periodontal status. J Dent Res. 2004, 73(8), 1397–1406.

19. Pirham D., Atilla G., Emingil G. et al. Eff ects of MMP-1 promoter polymorphisms on GCF MMP-1 levels and outcome of periodontal therapy in patients with severe chronic periodontitis. J Clin Periodontol. 2008, 35(10), 862–870.

20. Rai B., Kharb S., Jain R., Anand S. C. Biomarkers of periodontitis in oral fl uids. J Oral Science. 2008, 50(1), 53–56.

21. Soell M., Elkaim R., Tenenbaum H., Cathepsin C. Matrix metalloproteinases, and their tissue inhibitors in gingiva and gingival crevicular fl uid from periodontitisaff ected patients. J Dent Res. 2002, 81(3), 174–178.

22. Taylor J. J., Preshaw P. M., Lalla E. A review of the evidence for pathogenic mechanisms that may link periodontitis and diabetes. J Clin Periodontol. 2013 Apr, 40, 113–134.

23. Xu L., Yu Z., Lee H. M., Wollff M. S., Golub L. M. et al. Characteristics of collagenase-2 from gingival crevicular fl uid and peri-implant sulcular fl uid in periodontitis and peri-implantitis patients: pilot study. Acta Odontologica Scandinavica. 2008, 66, 219–224.

Система Orphus

Loading...
Up