The role of genetic and epigenetic factors in modulating the influence of early adverse experiences on development

 
PIIS020595920005460-2-1
DOI10.31857/S020595920005460-2
Publication type Article
Status Published
Authors
Occupation: Researcher, Laboratory of Translational Sciences of Human Development
Affiliation: Saint-Petersburg State University, University of Houston, Texas Institute for Measurement, Evaluation, and Statistics
Address: Russian Federation, Saint-Petersburg, Houston
Occupation: Junior researcher, Laboratory of Translational Sciences of Human Development
Affiliation: Saint-Petersburg State University, University of Houston, Texas Institute for Measurement, Evaluation, and Statistics
Address: Russian Federation, Saint-Petersburg, Houston
Occupation: Senior Researcher, Laboratory of Human Genetics, Vavilov Institute of General Genetics RAS
Affiliation: Vavilov Institute of General Genetics, Russian Academy of Sciences, University of Houston, Texas Institute for Measurement, Evaluation, and Statistics
Address: Russian Federation, Moscow, Houston
Occupation: Leading scientist of the Laboratory of Translational Sciences of Human Development
Affiliation: Saint-Petersburg State University, University of Houston, Texas Institute for Measurement, Evaluation, and Statistics
Address: Russian Federation, Saint-Petersburg, Houston
Journal namePsikhologicheskii zhurnal
EditionVolume 40 issue 5
Pages74-83
Abstract

The developmental outcome of early-life adverse experiences is considered with respect to the interaction between genetic and epigenetic factors. The mechanisms modulating the genome’s responses to environmental signals are illustrated by the discussion of the two genes that play a role in the neurohumoral response to stress, namely the serotonin transporter gene SLC6A4 and the glucocorticoid receptor gene NR3C1. Epigenetic mechanisms are considered as a modulator of these responses providing long-term changes in the phenotype. The reviewed literature highlights the need to combine information on the genome’s structure and its epigenetic status in the analysis of the impact of early-life adverse experience on subsequent development. Such combinatory analyses will also be beneficial for the purposes of personalized diagnosis and therapy of mental disorders.

KeywordsEpigenetic modifications of the genome, genetic polymorphisms, early-life experience, stress response, phenotype development.
AcknowledgmentPreparation of this article was carried out within the megagrant of the Government of the Russian Federation № 14.Z50.31.0027 “Influence of early deprivation on bio-behavioral indicators of child development”.
Received10.06.2019
Publication date04.09.2019
Number of characters24224
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