2018 Nobel Prize Laureates in Chemistry: Frances Arnold, George Smith, and Sir Gregory Winter

Publication type Article
Status Published
Novosibirsk State University
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of RAS
Address: Novosibirsk, Russia
Affiliation: Novosibirsk State University
Address: Novosibirsk, Russia
Journal namePriroda
EditionIssue №12

The 2018 Nobel Prize in Chemistry was awarded for discoveries in the field of protein design, which importance is difficult to overestimate these days. Dozens of different “designer” antibodies are used in medicine today, which were created on the basis of the methods developed by Frances H.Arnold, George P.Smith, and Sir Gregory P.Winter.

KeywordsNobel Prize, biocatalysis, molecular recognition, protein design, phage display, directed evolution of enzymes
Publication date14.01.2019
Cite   Download pdf To download PDF you should sign in
Размещенный ниже текст является ознакомительной версией и может не соответствовать печатной

views: 269

Readers community rating: votes 0

1. Eigen M., Gardiner W. Evolutionary molecular engineering based on RNA replication. Pure Appl. Chem. 1984; 56(8): 967–978.

2. Chen K., Arnold F.H. Tuning the activity of an enzyme for unusual environments: sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide. Proc. Natl Acad. Sci. USA. 1993; 90(12): 5618–5622.

3. Pinheiro V.B., Taylor A.I., Cozens C. et al. Synthetic genetic polymers capable of heredity and evolution. Science. 2012; 336(6079): 341–344. Doi:10.1126/science.1217622.

4. Kuzmicheva G.A., Belyavskaya V.A. Peptide phage display in biotechnology and biomedicine. Biochem. Moscow Suppl. Ser. B. 2017. 11(1): 1–15. Doi:10.1134/S1990750817010061.

5. Tikunova N.V., Morozova V.V. Phage Display on the Base of Filamentous Bacteriophages: Application for Recombinant Antibodies Selection. Acta Naturae. 2009; 1(3): 20–28.

6. Smith G.P. Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. Science. 1985; 228(4705): 1315–1317. Doi:10.1126/science.4001944.

7. McCafferty J., Griffiths A.D., Winter G. et al. Phage antibodies: filamentous phage displaying antibody variable domains. Nature. 1990; 348(6301): 552–554. Doi:10.1038/348552a0.

8. Jones P.T., Dear P.H., Foote J. et al. Replacing the complementarity#determining regions in a human antibody with those from a mouse. Nature. 1986; 321(6069): 522–525. Doi:10.1038/321522a0.

Система Orphus