New Approaches to the Development of Immunogen for HIV Vaccine

Publication type Article
Status Published
Ivanovsky Institute of Virology, Gamaleya Federal Research Center of Epidemiology and Microbiology
Faculty of Biology, Lomonosov Moscow State University
Address: Russian Federation, Moscow
Journal namePriroda
EditionIssue №11

The most effective anti-HIV antibodies capable of blocking extracellular and intracellular HIV are antibodies against conserved epitopes on the Env-trimer obtained from HIV-infected individuals. A multi-step strategy for the design of new immunogens based on Envtrimers has been developed. A strategy developed on the basis of the data obtained during the study of HIV escape from the immune response mechanisms was used for the modification. Modification of the cytoplasmic domain, made it possible to obtain stabilized open-form trimers. Another modification of the trans-membrane domain (TMS) in combination with the short cytoplasmic tail enhanced the incorporation of Env-trimers.

into viruslike particles (VLP). Stepbystep modification VLPbased immunogens are capable of inducing protective

high avidity and broadly neutralizing antibodies and have great potential for the development of HIV vaccines.

KeywordsHIV, broadly neutralizing antibodies, protective non-neutralizing antibodies, Env-trimers, immunogen design
Publication date11.12.2018
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