Estrogen receptors alpha and beta in ovarian cancer: expression level and prognosis

Bogush, Tatiana; Basharina, Anna; Bogush, Elena; Ryabinina, Olga; Tyulyandina, Alexandra; Tyulyandin, Sergey

doi:10.31857/S086956520003105-8

Home

Doklady Akademii nauk

Issue 3

Estrogen receptors alpha and beta in ovarian cancer: expression level and prognosis

Annotation
Reviews
References

Estrogen receptors alpha and beta in ovarian cancer: expression level and prognosis

PII

S086956520003105-8-1

DOI

10.31857/S086956520003105-8

Publication type

Article

Status

Published

Authors

Tatiana Bogush

Affiliation: N.N. Blokhin Russian Cancer Research Center of the Ministry of Health of the Russian Federation
Address: Russian Federation,

Anna Basharina

Affiliation:
N.N. Blokhin Russian Cancer Research Center of the Ministry of Health of the Russian Federation
Lomonosov Moscow State University
Address: Russian Federation

Elena Bogush

Affiliation: N.N. Blokhin Russian Cancer Research Center of the Ministry of Health of the Russian Federation
Address: Russian Federation

Olga Ryabinina

Affiliation: N.N. Blokhin Russian Cancer Research Center of the Ministry of Health of the Russian Federation
Address: Russian Federation

Alexandra Tyulyandina

Affiliation: N.N. Blokhin Russian Cancer Research Center of the Ministry of Health of the Russian Federation
Address: Russian Federation

Sergey Tyulyandin

Affiliation: N.N. Blokhin Russian Cancer Research Center of the Ministry of Health of the Russian Federation
Address: Russian Federation

Journal name

Doklady Akademii nauk

Edition

Volume 482 Issue 3

Pages

340-342

Abstract

The quantitative immunofluorescence assay of serous ovarian cancer tissue was revealed estrogen receptors (ERα and ERβ) expression in all the surgical tumor samples investigated a higher expression level of ERβ in comparison with ERα. Significant differences in the expression level of the markers were detected “from tumor to tumor”. A high level of expression both ERα (≥ 25%) and ERβ (≥ 44%) predicts a significantly longer free survival time (p  0,01) in the patients after the first line of platinum and taxane-based adjuvant chemotherapy.

Keywords

Received

08.11.2018

Publication date

08.11.2018

Cite Download pdf To download PDF you should sign in

GOST	Bogush T., Basharina A., Bogush E., Ryabinina O., Tyulyandina A., Tyulyandin S. Estrogen receptors alpha and beta in ovarian cancer: expression level and prognosis // Doklady Akademii nauk – 2018. – V. 482. – Issue 3 C. 340-342 [Electronic resource]. URL: http://ras.jes.su/dan/s086956520003105-8-1-en (circulation date: 18.05.2024). DOI: 10.31857/S086956520003105-8
MLA	Bogush, Tatiana, Basharina, Anna, Bogush, Elena, Ryabinina, Olga, Tyulyandina, Alexandra, Tyulyandin, Sergey "Estrogen receptors alpha and beta in ovarian cancer: expression level and prognosis." Doklady Akademii nauk 482.3 (2018):340-342. DOI: 10.31857/S086956520003105-8
APA	Bogush T., Basharina A., Bogush E., Ryabinina O., Tyulyandina A., Tyulyandin S. (2018). Estrogen receptors alpha and beta in ovarian cancer: expression level and prognosis. Doklady Akademii nauk 482(3), pp.340-342 DOI: 10.31857/S086956520003105-8

Размещенный ниже текст является ознакомительной версией и может не соответствовать печатной

Readers community rating: votes 0

1. Kucukgoz G.U., Gumurdulu D., Guzel A.B. et al. // Arch Gynecol Obstet. 2014. V. 289. № 2. P. 393–398.

2. Battista M.J., Mantai N., Sicking I. // Oncol Rep. 2014. V. 31. № 15. P. 2213-2219.

3. Bossard C., Busson M., Vindrieux D. et al. // PLoS One. 2012. V. 7. № 9. P. e44787.

4. Chang C.Y., McDonnell D.P. // Clin Cancer Res. 2012. V. 18. № 22. P. 6089-6095.

5. Bogush T.A., Tikhomirov M.V., Dudko E.A. i dr. // Vestn Mosk un-ta Ser. 2, Khimiya. 2012, T. 53. №3. S. 207 – 215.

6. Bogush T.A., Dudko E.A., Grishanina A.N.i dr. // DAN. 2016. T. 472. № 2. S. 215–218.