The paper analyzes the state of research on the phenomenon of responsibility in the scientific literature and its place within the framework of psychological knowledge, including in the context of professional and entrepreneurial activities. It is shown that the macropsychological analysis of the attitude of Russians to the social aspects of responsibility as a psychological phenomenon is an actual, but little studied problem. The study is aimed at identifying the structural and content characteristics of social network users' perceptions of professional responsibility as a unique (not identical) phenomenon to other types of responsibility. In accordance with the stated goal, there is an appeal to neural network automated methods for analyzing large amounts of information according to semantic, frequency and emotional criteria. The general classification of messages is made in the expert mode. The results of the study made it possible to formulate a number of main conclusions: responsibility is perceived as an inalienable component of professional activity; the greatest responsibility is attributed to professionals responsible for the well-being of others; the more people are in the sphere of distribution of the powers of a professional, the higher the level of responsibility attributed to him; professional responsibility gives rise to a wide range of different experiences, in the structure of which a dishonest attitude to the fulfillment of one's obligations causes extremely negative assessments. The paper reveals the principles of personalization and depersonalization of responsibility. In the future, an analysis of similar ideas of residents of other countries is proposed.